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SML0551

Sigma-Aldrich

淫羊藿素

≥98% (HPLC)

同義詞:

3,5,7-三羟基-2-（4-甲氧苯基）-8-（3-甲基-2-丁烯-1-基）-4H-1-苯并吡喃-4-酮

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About This Item

經驗公式（希爾表示法）:
C21H20O6
CAS號碼:
118525-40-9
分子量：:
368.38
MDL號碼:
MFCD22422519
分類程式碼代碼:
12352200
PubChem物質ID:
329825547
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

顏色

light yellow to dark yellow

溶解度

DMSO: 5 mg/mL, clear (warmed)

儲存溫度

2-8°C

SMILES 字串

COc1ccc(cc1)C2=C(O)C(=O)c3c(O)cc(O)c(C\C=C(\C)C)c3O2

InChI

1S/C21H20O6/c1-11(2)4-9-14-15(22)10-16(23)17-18(24)19(25)20(27-21(14)17)12-5-7-13(26-3)8-6-12/h4-8,10,22-23,25H,9H2,1-3H3

InChI 密鑰

TUUXBSASAQJECY-UHFFFAOYSA-N

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生化／生理作用

淫羊藿素促进间充质干细胞 (MSCs) 的成骨细胞分化，同时抑制 MSCs 的成脂分化。
淫羊藿素增强间充质干细胞 (MSCs) 的成骨细胞分化。可能具有类雌激素活性。
淫羊藿素是从淫羊藿中分离得到的一种淫羊藿黄酮成分，它通过抑制 PPAR-g 通路促进间充质干细胞 (MSCs) 向成骨细胞分化，同时抑制 MSCs 的成脂分化。淫羊藿素对 MSCs 增殖无影响。此外，淫羊藿素最有可能通过调节 MAPK/ERK/JNK 和 JAK2/STAT3/AKT 信号，有效抑制慢性髓样白血病 (CML) 和乳腺癌细胞增殖。淫羊藿素与其它黄酮类化合物一样，可能具有雌激素样活性。

特點和優勢

《受体分类和信号转导》手册的 JAK、MAPK 和 核受体（PPAR） 页面有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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分析證明 (COA)

Lot/Batch Number
037M4708V
112M4710V

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存取文件庫

Dong Yao et al.
PloS one, 7(8), e41264-e41264 (2012-09-07)
We found that Icaritin, an intestinal metabolite of Epimedium-derived flavonoids (EF) enhanced osteoblastic differentiation of mesenchymal stem cells (MSCs) only under osteogenic induction conditions. We also demonstrated its effect on inhibition of adipogenic differentiation of MSCs. Unlike the findings of
Hongchao Li et al.
Journal of cellular biochemistry (2018-11-06)
Glioblastoma (GBM) is a common and aggressive brain tumor that is associated with significant increase in glycolysis for energy production. Icaritin is a natural compound and exhibits anticancer activity in GBM. However, the effect of icaritin on glycolysis in GBM
Jing-Shan Tong et al.
PloS one, 6(3), e16781-e16781 (2011-03-17)
Icaritin, a compound from Epimedium Genus, has selective estrogen receptor (ER) modulating activities, and possess anti-tumor activity. Here, we examined icaritin effect on cell growth of human endometrial cancer Hec1A cells and found that icaritin potently inhibited proliferation of Hec1A
Jian feng Zhu et al.
PloS one, 6(8), e23720-e23720 (2011-09-03)
To explore the effects of Icaritin on chronic myeloid leukemia (CML) cells and underlying mechanisms. CML cells were incubated with various concentration of Icaritin for 48 hours, the cell proliferation was analyzed by MTT and the apoptosis was assessed with
Wing Pui Tsang et al.
Scientific reports, 7, 40894-40894 (2017-01-17)
Utilization of small molecules in modulation of stem cell self-renewal is a promising approach to expand stem cells for regenerative therapy. Here, we identify Icaritin, a phytoestrogen molecule enhances self-renewal of mouse embryonic stem cells (mESCs). Icaritin increases mESCs proliferation
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JAKs

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Nuclear Receptors (PPARs)

Peroxisome proliferator activated receptors (PPARs) are members of the nuclear hormone receptor superfamily of ligand-activated transcription factors that are related to retinoid, steroid and thyroid hormone receptors.

MAPKs

The mitogen-activated protein kinase (MAPK) family consists of both stress activated (SAPK) and mitogen-activated (MAPK) protein kinases. They form a network of signal transduction cascades that mediate cellular responses to a diverse range of stimuli, including growth factors, chemical or osmotic stress, irradiation, bacterial infection and proinflammatory cytokines.

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