H1917

Histone H1 human

• 同義詞: Histone, Human
• CAS號碼: 1523001-32-2
• 分類程式碼代碼: 12352202
• NACRES: NA.25

屬性

• 生物源: human
• 品質等級: 200
• 重組細胞: expressed in E. coli
• 形狀: liquid
• 濃度: 1 mg/mL
• UniProt登錄號: P07305
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 基因資訊: human ... H1.0(3005)

描述

一般說明

Histone H1 is part of high-order chromatin structure and is a linker protein associated with nucleosome core particle. Histone H1 is mapped to human chromosome 6. Histone H1 exists in different isoforms. Histone H1 comprises of N-terminal hydrophobic rich region, central globular domain and a C-terminal with intrinsically disordered regions.

生化／生理作用

The C-terminal regions of histone H1 is essential for binding to chromatin. The placement of H1 is necessary for nucleosome positioning. Histone H1 maintains chromosome architecture and stabilises compaction of nucleosomes during interphase. H1-null mutants display increased rate of chromatin aberration and growth defects. Histone H1 modulates embryogenesis and DNA repair. The H1 histone undergoes posttranslational modification including phosphorylation, methylation and acetylation, each of which carry out different physiological functions. Histone H1 and its variants contribute to the pathogenesis in cancer, Alzheimer′s disease, male infertility and immunity related disorders.

外觀

Supplied as 1 mg/mL in 20 mM NaPO₄, pH 7.0, 0.3 M NaCl, 1 mM EDTA, and 1 mM DTT.

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H319
• 防範說明: P264 - P280 - P305 + P351 + P338 - P337 + P313
• 危險分類: Eye Irrit. 2
• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable