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About This Item
經驗公式（希爾表示法）:
C7H13N3O4 · H2O
CAS號碼:
分子量：:
221.21
MDL號碼:
分類程式碼代碼:
12352209
PubChem物質ID:
NACRES:
NA.32
推薦產品
product name
Gly-Gln 一水合物, ≥97% (HPLC)
化驗
≥97% (HPLC)
儲存溫度
−20°C
SMILES 字串
O.NCC(=O)N[C@@H](CCC(N)=O)C(O)=O
InChI
1S/C7H13N3O4.H2O/c8-3-6(12)10-4(7(13)14)1-2-5(9)11;/h4H,1-3,8H2,(H2,9,11)(H,10,12)(H,13,14);1H2/t4-;/m0./s1
InChI 密鑰
KLFWVRQACSYLOH-WCCKRBBISA-N
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Amino Acid Sequence
Gly-Gln
一般說明
甘氨酰谷氨酰胺（gly-gln）是一种二肽，在细胞培养中用作谷氨酰胺的替代物。当使用该二肽代替谷氨酰胺时，由于 gly-gln 影响底物利用和代谢，可获得更高的细胞产量。由于较低的肽酶亲和力，该二肽的浓度维持很高，细胞生长较快。
Glycyl-glutamine is a dipeptide form of L-glutamine. Gly-Gln dipeptide exhibits enhanced solubility and thermostability. Moreover, this compound rapidly hydrolyzes into glutamine and glycine following intravenous infusion. Glycine can protect myocardial cells from ischemic injury by preventing cellular membrane permeability. Furthermore, the supplementation of glycyl-glutamine dipeptide proves advantageous for myocardial preservation in rats, as it enhances cardiocyte energy metabolism and augments ATP and glutathione synthesis.
應用
Gly-Gln monohydrate has been used:
- as a supplement in Dulbecco′s modified Eagle medium (DMEM) to culture equine embryos
- as a supplement in DMEM/F-12 to culture cleaved horse embryos
- in the human tubal fluid (HTF) medium to study ammonium accumulation in commercially available embryo culture media during incubation and storage
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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A Christie et al.
Journal of biotechnology, 37(3), 277-290 (1994-11-15)
A murine hybridoma (CC9C10) was grown in media containing alanyl-glutamine (ala-gln) or glycyl-glutamine (gly-gln) as a substitute for glutamine. High cell yields were obtained in the presence of 6 mM ala-gln or 20 mM gly-gln. The final cell yield in
Parish, D.C. and Smyth, D.G.
Biochemical Society Transactions, 10, 221-221 (1982)
Sander H M Kleijkers et al.
Human reproduction (Oxford, England), 31(6), 1192-1199 (2016-04-08)
Does ammonium accumulate in commercially available culture media and protein supplements used for in vitro development of human pre-implantation embryos during storage and incubation? Ammonium accumulates in ready-to-use in vitro fertilization (IVF) culture media during storage at 2-8°C and in
D C Parish et al.
Nature, 306(5940), 267-270 (1983-11-17)
The primary mechanism of activation of intracellular prohormones seems to involve proteolytic cleavage at sequences of consecutive basic residues. Thus, all the known biologically active peptides derived from the prohormone of corticotropin and beta-endorphin appear to be excised initially by
E Roth et al.
In vitro cellular & developmental biology : journal of the Tissue Culture Association, 24(7), 696-698 (1988-07-01)
The instability of the amino acid glutamine prompted us to investigate substitute compounds appropriate for culture conditions. The effect of two glutamine-containing dipeptides, alanylglutamine (Ala-Gln) and glycylglutamine (Gly-Gln), on the growth behavior of a hematopoietic cell line in culture (K562)
文章
L-谷氨酰胺在杂交瘤细胞和哺乳动物细胞培养中的重要性和应用
Importance and uses of glutamine in hybridoma and mammalian cell culture
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