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Merck
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重要文件

F7016

Sigma-Aldrich

氟甲喹

≥97.0% (HPLC)

同義詞:

9-Fluoro-5-methyl-1-oxo-1,5,6,7-tetrahydropyrido[3,2,1-ij]quinoline-2-carboxylic acid

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About This Item

經驗公式(希爾表示法):
C14H12FNO3
CAS號碼:
分子量::
261.25
Beilstein:
490724
EC號碼:
MDL號碼:
分類程式碼代碼:
51102829
PubChem物質ID:
NACRES:
NA.85

化驗

≥97.0% (HPLC)

形狀

powder

顏色

white to off-white

抗生素活性譜

Gram-negative bacteria
Gram-positive bacteria

作用方式

DNA synthesis | interferes
enzyme | inhibits

SMILES 字串

CC1CCc2cc(F)cc3C(=O)C(=CN1c23)C(O)=O

InChI

1S/C14H12FNO3/c1-7-2-3-8-4-9(15)5-10-12(8)16(7)6-11(13(10)17)14(18)19/h4-7H,2-3H2,1H3,(H,18,19)

InChI 密鑰

DPSPPJIUMHPXMA-UHFFFAOYSA-N

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一般說明

化学结构:氟喹诺酮

生化/生理作用

泛黄素抑制拓扑异构酶,这是细菌 DNA 转录和复制所必需的。拓扑异构酶的抑制导致细菌染色体的链断裂、超螺旋和重新封闭。因此,DNA 复制和转录被抑制。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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分析證明 (COA)

Lot/Batch Number

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E Giraud et al.
Antimicrobial agents and chemotherapy, 43(9), 2131-2137 (1999-09-03)
The occurrence of mutations in the genes coding for gyrase (gyrA and gyrB) and topoisomerase IV (parE and parC) of Salmonella typhimurium experimental mutants selected in vitro and in vivo and of 138 nalidixic acid-resistant Salmonella field isolates was investigated.
I Guillemin et al.
Microbiology (Reading, England), 145 ( Pt 9), 2527-2532 (1999-10-12)
The DNA gyrases from Mycobacterium avium, Mycobacterium smegmatis and Mycobacterium fortuitum bv. peregrinum, which are species naturally resistant, moderately susceptible and susceptible to fluoroquinolones, respectively, were purified by affinity chromatography on novobiocin-Sepharose columns. The DNA gyrase inhibiting activities (IC50 values)
Yoko Kashida et al.
Toxicological sciences : an official journal of the Society of Toxicology, 69(2), 317-321 (2002-10-16)
In order to elucidate the tumor-initiating potential of flumequine (FL) in the liver, male C3H mice were given dietary administration of 4000 ppm FL throughout the study or for 2 weeks at the initiation stage, and then received 2 intraperitoneal
Etienne Giraud et al.
Journal of medical microbiology, 53(Pt 9), 895-901 (2004-08-18)
The mechanisms of resistance to quinolone and epidemiological relationships among A. salmonicida strains isolated from diseased fish in French marine farms from 1998 to 2000 were investigated. The quinolone resistance-determining regions of the gyrA and parC genes of 12 clinical
C Ferraresi et al.
Poultry science, 92(12), 3158-3165 (2013-11-16)
Flumequine (FLU) is used in the treatment of systemic bacterial infections in poultry, including colibacillosis, which is a common disease in turkeys. The pharmacokinetic (PK) behavior of FLU administered to 32 healthy turkeys as an oral bolus via gavage or

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