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Merck
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重要文件

F9505

Sigma-Aldrich

呋喃唑酮

同義詞:

3-(5-硝基呋喃甲叉氨基)-2-噁唑烷酮

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About This Item

經驗公式(希爾表示法):
C8H7N3O5
CAS號碼:
分子量::
225.16
Beilstein:
8317414
EC號碼:
MDL號碼:
分類程式碼代碼:
51102829
PubChem物質ID:
NACRES:
NA.85

生物源

synthetic

品質等級

形狀

powder

顏色

yellow

mp

256-256 °C

溶解度

formic acid: 50 mg/mL

抗生素活性譜

Gram-positive bacteria
parasites

作用方式

enzyme | inhibits

SMILES 字串

[O-][N+](=O)c1ccc(\C=N\N2CCOC2=O)o1

InChI

1S/C8H7N3O5/c12-8-10(3-4-15-8)9-5-6-1-2-7(16-6)11(13)14/h1-2,5H,3-4H2/b9-5+

InChI 密鑰

PLHJDBGFXBMTGZ-WEVVVXLNSA-N

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應用

呋喃唑酮是硝基呋喃衍生物,具有抗原虫和抗菌活性。呋喃唑酮与细菌 DNA 结合,从而导致单胺氧化酶逐渐受到抑制。用于治疗厌食和拮抗家禽对硫胺素的利用 。呋喃唑酮增加鸡心肌细胞中对毒胡萝卜素敏感的 Ca 2+-atp 酶

生化/生理作用

呋喃唑酮及其产生的自由基,可能与 DNA 结合并诱导交联。细菌 DNA 对本药特别敏感,从而导致细菌染色体的高水平突变(转换和颠换)。其作用机制使耐药生物体的发展最小化。呋喃唑酮是一种单胺氧化酶 (MAO) 抑制剂,用作 DNA 链间交联剂。

象形圖

Health hazard

訊號詞

Warning

危險聲明

危險分類

Repr. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

個人防護裝備

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges


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