O5875

土霉素盐酸盐 盐酸盐

• 同義詞: 5-Hydroxytetracycline hydrochloride
• 經驗公式（希爾表示法）: C₂₂H₂₄N₂O₉ · HCl
• CAS號碼: 2058-46-0
• 分子量：: 496.89
• Beilstein: 3853107
• EC號碼: 218-161-2
• MDL號碼: MFCD00135815
• 分類程式碼代碼: 51284039
• PubChem物質ID: 24898027
• NACRES: NA.85

屬性

• 形狀: powder or crystals
• 品質等級: 200
• 雜質: ≤3.5% total of impurities (related substances (HPLC))
• 顏色: yellow
• 溶解度: soluble
• 抗生素活性譜: Gram-negative bacteria; Gram-positive bacteria
• 作用方式: protein synthesis | interferes
• SMILES 字串: Cl.CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)cccc4[C@@]3(C)O
• InChI: 1S/C22H24N2O9.ClH/c1-21(32)7-5-4-6-8(25)9(7)15(26)10-12(21)17(28)13-14(24(2)3)16(27)11(20(23)31)19(30)22(13,33)18(10)29;/h4-6,12-14,17,25,27-29,32-33H,1-3H3,(H2,23,31);1H/t12-,13-,14+,17+,21-,22+;/m1./s1
• InChI 密鑰: UBDNTYUBJLXUNN-IFLJXUKPSA-N

描述

一般說明

Chemical structure: tetracycline

Freely soluble in water, sparingly soluble in Ethanol (96%). Solution in water becomes turbid on standing owing to the precipitation of chromatograms.

應用

Oxytetracycline is a tetracycline analog isolated from the actinomycete Streptomyces rimosus. Oxytetracycline is an antibiotic indicated for treatment of infections caused by Gram positive and Gram negative microorganisms such as Mycoplasma pneumoniae, Pasteurella pestis, Escherichia coli, Haemophilus influenzae, and Diplococcus pneumoniae. It is used in studies on the oxytetracycline-resistance gene (otrA). Oxytetracycline hydrochloride is used to study phagosome-lysosome (P-L) fusion in P388D1 cells and antibiotic susceptibilities of Mycoplasma bovis isolates.

生化／生理作用

Mode of Action: Inhibits protein synthesis (elongation) by preventing binding of aminoacyl-tRNA to the 30S subunit.
Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
Mode of Resistance: Active efflux, ribosome protection, tetracycline inactivation.

Oxytetracycline inhibits translation which results in cell death. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. The binding is reversible in nature. Oxytetracycline is lipophilic so it can easily pass through a cell membrane and passively diffuses through channels in the bacterial membrane.

其他說明

10g,50g,100g

Keep container tightly closed in a dry and well-ventilated place.Store under inert gas. Light sensitive.Air sensitive.

安全資訊

• 象形圖: GHS08
• 訊號詞: Warning
• 危險聲明: H361fd
• 防範說明: P201 - P202 - P280 - P308 + P313 - P405 - P501
• 危險分類: Repr. 2
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)