EPS003

CUDC 101

A potent inhibitor of HDACs and receptor tyrosine kinases

• 同義詞: 7-[[4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yl]oxy]-N-hydroxyheptanamide, Heptanamide, 7-[[4-[(3-ethynylphenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-N-hydroxy
• 經驗公式（希爾表示法）: C₂₄H₂₆N₄O₄
• CAS號碼: 1012054-59-9
• 分子量：: 434.49
• MDL號碼: MFCD15528940
• 分類程式碼代碼: 12352200
• NACRES: NA.41

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 顏色: white
• 溶解度: DMSO: soluble
• 儲存溫度: −20°C
• SMILES 字串: N(O)C(=O)CCCCCCOc1cc2c(ncnc2Nc3cc(ccc3)C#C)cc1OC
• InChI: 1S/C24H26N4O4/c1-3-17-9-8-10-18(13-17)27-24-19-14-22(21(31-2)15-20(19)25-16-26-24)32-12-7-5-4-6-11-23(29)28-30/h1,8-10,13-16,30H,4-7,11-12H2,2H3,(H,28,29)(H,25,26,27)
• InChI 密鑰: PLIVFNIUGLLCEK-UHFFFAOYSA-N

描述

一般說明

A potent multitargeted inhibitor of histone deacetylase (HDAC) and the receptor kinases epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), with IC50 values of 4.4, 2.4, and 15.7 nM, respectively.

Displays potent antiproliferative and proapoptotic activities against cultured and implanted tumor cells that are sensitive or resistant to several approved single-targeted drugs.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable