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C9521

Sigma-Aldrich

Z-Phe-Arg 7-酰氨基-4-甲基香豆素 盐酸盐

kallikrein substrate, ≥95% (HPLC), powder

同義詞:

Z-Phe-Arg-AMC

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About This Item

經驗公式(希爾表示法):
C33H36N6O6 · HCl
CAS號碼:
分子量::
649.14
MDL號碼:
分類程式碼代碼:
12352204
PubChem物質ID:
NACRES:
NA.32

product name

Z-Phe-Arg 7-酰氨基-4-甲基香豆素 盐酸盐, kallikrein substrate

品質等級

化驗

≥95% (HPLC)

形狀

powder

濃度

≥95%

溶解度

methanol: 20 mg/mL, clear, colorless

儲存溫度

−20°C

SMILES 字串

O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCCNC(N)=N)C(NC2=CC=C(C(C)=CC(O3)=O)C3=C2)=O)=O)OCC4=CC=CC=C4.[Cl]

InChI

1S/C33H36N6O6/c1-21-17-29(40)45-28-19-24(14-15-25(21)28)37-30(41)26(13-8-16-36-32(34)35)38-31(42)27(18-22-9-4-2-5-10-22)39-33(43)44-20-23-11-6-3-7-12-23/h2-7,9-12,14-15,17,19,26-27H,8,13,16,18,20H2,1H3,(H,37,41)(H,38,42)(H,39,43)(H4,34,35,36)

InChI 密鑰

ZZGDDBWFXDMARY-UHFFFAOYSA-N

一般說明

Z-苯丙氨酸-精氨酸 7-氨基-4-甲基香豆素(Z-FR-AMC)是一种拟肽类底物,可用于木瓜蛋白酶和其它酶,如组织蛋白酶K。它也是组织蛋白酶L和B的荧光合成肽。

應用

Z-苯丙氨酸-精氨酸7-氨基-4-甲基香豆盐酸盐已被用于:
  • 作为猕猴桃碱抑制检测中的荧光底物
  • 作为血管舒缓素底物
  • 作为荧光检测的胰蛋白酶底物
  • 作为组织蛋白酶-L底物

生化/生理作用

由蛋白酶引发的Z-苯丙氨酸-精氨酸7-氨基-4-甲基香豆素(Z-FR-AMC)的蛋白水解性裂解导致AMC的释放,结果使酶反应中的荧光增强。

基底

一种用于血浆激肽释放酶的荧光底物。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析證明 (COA)

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L Troeberg et al.
Immunopharmacology, 36(2-3), 295-303 (1997-06-01)
Anti-peptide antibodies were produced against the cysteine proteinase trypanopain-Tb from Trypanosoma brucei brucei and the effects of these antibodies on enzyme activity against carboxybenzoyl (Z)-Phe-Arg-aminomethylcoumarin (AMC) investigated. A peptide was synthesised corresponding to a region of the trypanopain-Tb active site
L Salvati et al.
European journal of biochemistry, 268(11), 3253-3258 (2001-06-08)
Cysteine proteinases are relevant to several aspects of the parasite life cycle and of parasite-host relationships. Here, a quantitative investigation of the effect of temperature and pH on the total substrate inhibition of cruzipain, the major papain-like cysteine proteinase from
Cinthia Bernardes Gomes et al.
Biochimie, 133, 28-36 (2016-12-07)
Leishmania (Viannia) braziliensis presents adaptive protease-dependent mechanisms, as cysteine proteinases B (CPB). This study investigates the expression of three cpb gene isoforms and CPB enzymatic activity during the parasite differentiation. Relative expression levels of LbrM.08.0810 gene were assessed, exhibiting a
E Dufour et al.
Biochemistry, 34(28), 9136-9143 (1995-07-18)
Enzymes efficiently catalyze reactions by stabilizing inherently unstable transition states. For cysteine proteases, part of the stabilization is provided by a region of the enzyme termed the oxyanion hole. Site-directed mutagenesis has been used to investigate further the role of
Early ontogenetic development, digestive enzymatic activity and gene expression in red sea bream (Pagrus major)
Khoa TND, et al.
Aquaculture (Amsterdam, Netherlands), 512, 734283-734283 (2019)

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