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Merck
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重要文件

C7752

Sigma-Aldrich

细胞色素 C 来源于马心脏

≥95% based on Mol. Wt. 12,384 basis

同義詞:

Cytochrome c 来源于马心脏

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About This Item

CAS號碼:
9007-43-6
EC號碼:
232-700-9
MDL號碼:
MFCD00130890
分類程式碼代碼:
12352202
NACRES:
NA.61

生物源

horse heart

化驗

≥95% (SDS-PAGE)
≥95% based on Mol. Wt. 12,384 basis

形狀

powder

分子量

12,384

技術

cell culture | mammalian: suitable

適合性

suitable for molecular biology

UniProt登錄號

P00004

儲存溫度

−20°C

基因資訊

horse ... CYCS(100053958)

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應用

在各种研究中，细胞色素 c 被用作线粒体依赖性细胞凋亡的诱导剂。细胞色素 c 中氧化位点的识别和监测可能对评估氧化应激相关病症和疾病具有重要意义。它有可能用作评估氧化损伤程度以及细胞和组织抗氧化能力的生物标志物。

细胞色素 c 适合用作磷酸盐缓冲液的成分，用于采用蓝色天然凝胶电泳（BN-PAGE）检测和评估复合物 IV 活性。它还可用于检测分离的肾脏吞噬细胞中的细胞外超氧阴离子 (ECSA)。
马的细胞色素c经过H2O2和UV 处理后的特异性位点和氧化程度已经过表征。研究表明这些位点可能可用作细胞内氧化环境的生物标记。

生化／生理作用

细胞色素c的主要身份是电子载体线粒体蛋白。在细胞内，细胞色素c能够在二价铁和三价铁之间转化，使得它称为了有效的生物电子载体，在动植物细胞内氧化中起到很重要的作用。它通常被视作呼吸作用催化剂，在呼吸底物和氧气之间形成必需的电子桥
细胞色素c被认为是凋亡途径中的重要中介体。线粒体细胞色素c释放，进入细胞质，激发细胞凋亡，通常被作为细胞凋亡过程的指示剂。

準備報告

醋酸制备，不需要TCA。

其他說明

想要了解更多细胞色素c和电子传递的信息，请访问www.sigma-aldrich.com/enzymeexplorer.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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分析證明 (COA)

Lot/Batch Number
SLCM1100
SLCF9928
SLBW6744
SLBQ2827V
SLBP7245V

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Ferricytochrome c binding to cardiolipin-containing liposomes produces a heterogeneous distribution of conformations comprising native-like and non-native misfolded proteins. We utilized the photoreduction of native ferricytochrome c in the presence of potassium ferrocyanide and resonance Raman spectroscopy to probe the population of native
Marilena Carbone et al.
Data in brief, 28, 104842-104842 (2019-12-24)
We present SEM, ThT fluorescence and circular dichroism (CD) data of amyloidogenic aggregates of cytochrome c (cyt c).This protein is of outmost relevance in many biochemical processes, such as respiratory chain in mitochondria and cells apoptosis. The present data focus
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Many proteins of the mitochondrial intermembrane space (IMS) contain structural disulfide bonds formed by the mitochondrial disulfide relay. In fungi and animals, the sulfhydryl oxidase Erv1 'generates' disulfide bonds that are passed on to the oxidoreductase Mia40, which oxidizes substrate
A H Mulder et al.
Clinical and experimental immunology, 98(2), 270-278 (1994-11-01)
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