跳轉至內容
Merck
全部照片(2)

文件

C4461

Sigma-Aldrich

硫酸粘杆菌素 硫酸盐

≥19,000 IU/mg

同義詞:

多粘菌素E

登入查看組織和合約定價
全部照片(2)

About This Item

CAS號碼:
1264-72-8
EC號碼:
215-034-3
MDL號碼:
MFCD00146495
分類程式碼代碼:
51102829
eCl@ss:
34050906
NACRES:
NA.85

形狀

powder

比活性

≥19,000 IU/mg

抗生素活性譜

Gram-negative bacteria

作用方式

cell membrane | interferes

儲存溫度

2-8°C

InChI

1S/C53H100N16O13.H2O4S/c1-9-30(6)12-10-11-13-41(72)60-33(14-20-54)48(77)69-43(32(8)71)53(82)65-36(17-23-57)45(74)64-38-19-25-59-52(81)42(31(7)70)68-49(78)37(18-24-58)62-44(73)34(15-21-55)63-50(79)39(26-28(2)3)67-51(80)40(27-29(4)5)66-46(75)35(16-22-56)61-47(38)76;1-5(2,3)4/h28-40,42-43,70-71H,9-27,54-58H2,1-8H3,(H,59,81)(H,60,72)(H,61,76)(H,62,73)(H,63,79)(H,64,74)(H,65,82)(H,66,75)(H,67,80)(H,68,78)(H,69,77);(H2,1,2,3,4)/t30?,31-,32-,33+,34+,35+,36+,37+,38+,39+,40-,42+,43+;/m1./s1

InChI 密鑰

ZJIWRHLZXQPFAD-LRYSGCCDSA-N

尋找類似的產品？ 前往 產品比較指南

一般說明

化学结构：肽

應用

硫酸粘杆菌素被用于透化细菌细胞膜以及研究甘露糖抗性血凝和某些生物体(如鲍曼不动杆菌 A. baumannii )的抗生素耐药性。 它已被用于研究大鼠肾脏hephrotoxicity毒性 ，以及对铜绿假单胞菌的MIC值、时间杀灭动力学和抗生素后效应（PAE） 。

生化／生理作用

作用机制：与革兰氏阴性菌细胞质膜上的脂质结合并破坏细胞壁完整性。
抗菌谱： 革兰氏阴性菌。
作用机制：与革兰氏阴性菌细胞质膜上的脂质结合并破坏细胞壁完整性。
抗菌谱： 革兰氏阴性菌。硫酸粘杆菌素的肾重吸收被认为可能涉及到有机阳离子转运蛋白和肽转运蛋白，并且该过程对pH敏感 。

分析報告

易溶于水，几乎不溶于丙酮和乙醇（96％）

其他說明

保持容器密闭，置于干燥通风处。

相關產品

產品號碼
描述
訂價

象形圖

Skull and crossbones
GHS06

訊號詞

Danger

危險聲明

H301

危險分類

Acute Tox. 3 Oral

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。

已經擁有該產品？

您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

Peng Cui et al.
Antimicrobial agents and chemotherapy, 60(11), 6867-6871 (2016-09-08)
Persisters are small populations of quiescent bacterial cells that survive exposure to bactericidal antibiotics and are responsible for many persistent infections and posttreatment relapses. However, little is known about how to effectively kill persister bacteria. In the work presented here
Deepesh Nagarajan et al.
Science advances, 5(7), eaax1946-eaax1946 (2019-07-30)
Drug resistance is a public health concern that threatens to undermine decades of medical progress. ESKAPE pathogens cause most nosocomial infections, and are frequently resistant to carbapenem antibiotics, usually leaving tigecycline and colistin as the last treatment options. However, increasing
Lisa M Leung et al.
Journal of clinical microbiology, 57(3) (2018-12-21)
Acinetobacter baumannii is a prevalent nosocomial pathogen with a high incidence of multidrug resistance. Treatment of infections due to this organism with colistin, a last-resort antibiotic of the polymyxin class, can result in the emergence of colistin-resistant strains. Colistin resistance
Lang Sun et al.
Antimicrobial agents and chemotherapy, 64(6) (2020-04-02)
Polymyxins are increasingly used as the critical last-resort therapeutic options for multidrug-resistant Gram-negative bacteria. Unfortunately, polymyxin resistance has increased gradually over the past few years. Although studies on polymyxin mechanisms are expanding, systemwide analyses of the underlying mechanism for polymyxin
José María Saugar et al.
Antimicrobial agents and chemotherapy, 50(4), 1251-1256 (2006-03-30)
Acinetobacter baumannii has successfully developed resistance against all common antibiotics, including colistin (polymyxin E), the last universally active drug against this pathogen. The possible widespread distribution of colistin-resistant A. baumannii strains may create an alarming clinical situation. In a previous
查看所有相關論文

我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.

聯絡技術服務