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Key Documents

P4932

Sigma-Aldrich

多粘菌素 B 硫酸盐

powder, non-animal origin, suitable for cell culture, BioReagent

同義詞:

Polymixin, Polymixin B, Polymixin B sulfate

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About This Item

經驗公式(希爾表示法):
C55H96N16O13 · 2H2SO4
CAS號碼:
分子量::
1385.61
EC號碼:
MDL號碼:
分類程式碼代碼:
12352207
NACRES:
NA.76

product name

多粘菌素 B 硫酸盐, powder, BioReagent, suitable for cell culture

產品線

BioReagent

品質等級

形狀

powder

效力

≥6,000 USP units per mg

技術

cell culture | mammalian: suitable

抗生素活性譜

Gram-negative bacteria

作用方式

cell membrane | interferes

儲存溫度

2-8°C

SMILES 字串

O=C(C(NC(C(CCN)NC(CCCCC(C)CC)=O)=O)C(C)O)NC(CCN)C(NC(CCNC(C(NC(C(NC(C(CCN)N1)=O)CCN)=O)C(O)C)=O)C(NC(CCN)C(NC(CC2=CC=CC=C2)C(NC(CC(C)C)C1=O)=O)=O)=O)=O.O=S(O)(O)=O

InChI

1S/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)

InChI 密鑰

HNDFYNOVSOOGDU-UHFFFAOYSA-N

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一般說明

Polymyxin B is a member of the polymyxin group of antibiotics, obtained from different strains of Bacillus polymyxa and related species. It contains a cyclic heptapeptide unit and a tripeptide side chain, which is N-acylated by a fatty acyl residue. Polymyxin B sulfate salt is generally used for the treatment of Gram-negative bacterial infections.
Chemical structure: peptide

應用

Polymyxin B sulfate salt has been used:
  • for the treatment of BAC-1.2F5 murine macrophages as an LPS (lipopolysaccharide) inhibitor
  • as positive and negative control during microbicidal concentration (MCC) assay

生化/生理作用

Polymyxin B sulfate has been used clinically to treat infections of the urinary tract, meninges and blood stream caused by susceptible strains of Pseudomonas aeruginosa. It also has been used in studying multidrug-resistant pathogens, as an immobilized agent for removal of endotoxins, and to induce pore formation in the membranes of cortex cells from excised sorghum roots.
作用机制:多粘菌素B硫酸盐结合到细菌脂多糖的脂质部分†上,通过诱导足够大的孔来破坏细胞质膜,使核苷酸泄漏到细菌的细胞壁中。 这可破环细胞质膜的半透性。

抗菌谱:对大多数革兰氏阴性杆菌,包括 大肠杆菌 ,真菌和革兰氏阳性菌都有杀菌作用。

注意

As supplied, the product should be stored at 2-8°C in the dark. No change was observed in retained samples after three years′ of storage in these conditions. Stock solutions should be sterile filtered and stored at 2-8°C. They are stable at 37°C for 5 days.

準備報告

Polymyxin B sulfate is soluble in water at 50 mg/mL, producing a very slightly hazy, colorless to yellow solution. It has only minimal solubility in any organic solvent. For example, it has a solubility of 0.115 mg/mL in ethanol.

其他說明

1mu,5mu
Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


分析證明 (COA)

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Sineenart Sengyee et al.
PLoS neglected tropical diseases, 12(2), e0006287-e0006287 (2018-02-24)
Burkholderia pseudomallei is an environmental bacterium that causes melioidosis, a major community-acquired infection in tropical regions. Melioidosis presents with a range of clinical symptoms, is often characterized by a robust inflammatory response, may relapse after treatment, and results in high
M C Skinner et al.
Antimicrobial agents and chemotherapy, 53(4), 1482-1489 (2009-02-04)
A topical microbicide that women can use to prevent sexually transmitted diseases (STDs) is essential, and many microbicide candidates are being tested for activity against human immunodeficiency virus and other STDs, including Chlamydia trachomatis. Screening assays for assessing the activity
J W Kang et al.
Journal of chromatography. A, 879(2), 211-218 (2000-07-13)
A capillary zone electrophoresis method for analysis of polymyxin B sulfate is described. In this method, triethanolamine (TEA)-phosphate buffer at pH 2.5 was employed to reduce the adsorption of analyte onto the capillary wall. Methyl-beta-cyclodextrin (M-beta-CD) and 2-propanol (IPA) were
Franz G Zingl et al.
Cell host & microbe, 27(2), 225-237 (2020-01-07)
Gram-negative bacteria release outer membrane vesicles into the external milieu to deliver effector molecules that alter the host and facilitate virulence. Vesicle formation is driven by phospholipid accumulation in the outer membrane and regulated by the phospholipid transporter VacJ/Yrb. We use
P Dello Sbarba et al.
Cytokine, 8(6), 488-494 (1996-06-01)
Macrophage colony-stimulating factor (M-CSF) is the main growth factor for mononuclear phagocytes. Responsiveness to growth factors is reduced in the course of functional activation of macrophages. We studied the interference of the macrophage activator interleukin 2 (IL-2) with the response

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