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Key Documents

C0780

Sigma-Aldrich

一水肌酸

suitable for cell culture

同義詞:

N-胺肉胺酸, α-甲胍乙酸

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About This Item

線性公式:
H2NC(=NH)N(CH3)CH2CO2H
CAS號碼:
分子量::
131.13
Beilstein:
907175
EC號碼:
MDL號碼:
分類程式碼代碼:
12352209
PubChem物質ID:
NACRES:
NA.26

product name

一水肌酸, anhydrous

等級

anhydrous

品質等級

形狀

powder

技術

cell culture | mammalian: suitable

顏色

white

SMILES 字串

CN(CC(O)=O)C(N)=N

InChI

1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9)

InChI 密鑰

CVSVTCORWBXHQV-UHFFFAOYSA-N

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應用

肌酸(Cr)和磷酸肌酸(PCr)通过肌酸激酶的作用主要在骨骼肌组织中快速产生ATP。肌酸可用作研究其摄取机制和作用代谢的补充剂。

生化/生理作用

肌酸是一种含氮化合物,可充当 ATP 快速再生的高能量储存库。大约 95% 的肌酸存在于骨骼肌中,主要为磷酸肌酸。肌酸可通过饮食摄入,也可由 L-精氨酸、甘氨酸和 L-蛋氨酸在肾脏和肝脏发生的多步骤反应中形成。肌酸随后被转运至肌肉组织。肌酸补充剂主要通过增加肌肉质量来增强运动成绩。肌酸还被研究用于神经肌肉疾病的治疗,可能有助于神经保护和改善细胞生物能量状态。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


分析證明 (COA)

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Philippe Généreux et al.
Journal of the American College of Cardiology, 65(6), 533-543 (2015-02-14)
Bifurcation lesions are frequent among patients with symptomatic coronary disease treated by percutaneous coronary intervention. Current evidence recommends a conservative (provisional) approach when treating the side branch (SB). The TRYTON (Prospective, Single Blind, Randomized Controlled Study to Evaluate the Safety
Subrata Patra et al.
Amino acids, 42(6), 2319-2330 (2011-07-20)
The creatine/creatine kinase (CK) system plays a key role in cellular energy buffering and transport. In vertebrates, CK has four isoforms expressed in a tissue-specific manner. In the process of creatine biosynthesis several other important metabolites are formed. The anticancer
Gregg W Stone et al.
JACC. Cardiovascular interventions, 8(7), 927-936 (2015-05-25)
This study sought to determine whether pre-percutaneous coronary intervention (PCI) plaque characterization using near-infrared spectroscopy identifies lipid-rich plaques at risk of periprocedural myonecrosis and whether these events may be prevented by the use of a distal protection filter during PCI.
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Amino acids, 40(5), 1271-1296 (2011-03-31)
The pleiotropic effects of creatine (Cr) are based mostly on the functions of the enzyme creatine kinase (CK) and its high-energy product phosphocreatine (PCr). Multidisciplinary studies have established molecular, cellular, organ and somatic functions of the CK/PCr system, in particular
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The Journal of clinical investigation, 124(11), 4915-4925 (2014-10-02)
Animal models suggest that acetylcarnitine production is essential for maintaining metabolic flexibility and insulin sensitivity. Because current methods to detect acetylcarnitine involve biopsy of the tissue of interest, noninvasive alternatives to measure acetylcarnitine concentrations could facilitate our understanding of its

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