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Key Documents

C4255

Sigma-Aldrich

肌酸酐

anhydrous, ≥98%

同義詞:

2-亚氨基-1-甲基咪唑啉-4-酮, 2-亚氨基-N-甲基乙内酰脲, 2-氨基-1-甲基-2-咪唑啉-4-酮

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About This Item

經驗公式(希爾表示法):
C4H7N3O
CAS號碼:
分子量::
113.12
Beilstein:
112061
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22

等級

anhydrous

品質等級

化驗

≥98%

形狀

powder

mp

295 °C (dec.) (lit.)

SMILES 字串

CN1CC(=O)N=C1N

InChI

1S/C4H7N3O/c1-7-2-3(8)6-4(7)5/h2H2,1H3,(H2,5,6,8)

InChI 密鑰

DDRJAANPRJIHGJ-UHFFFAOYSA-N

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一般說明

肌酐是在肌肉来源的磷酸肌酸降解过程中产生的分解产物。几乎所有肌酐都由肾脏从血液中滤过并排到尿液中,从而排出体外。血清肌酐是肾功能的最常用指标。在化学合成中,肌酐作为杂环含氮化合物,可产生富电子和强碱性肌酐衍生物。

應用

肌酐可用于:
  • 作为氮供体构筑块(building block)制备含氮杂环衍生物。
  • 作为反应剂合成供体-受体氮化碳共聚物,该共聚物可用作制氢光催化剂。
  • 作为起始材料经由肌酐氯胺的形成制备creatol(肌酐醇)(2-氨基-1,5-二氢-5-羟甲基咪唑-4-酮)。
  • 作为反应剂与各种靛红通过金催化的羟醛化作用合成3-取代-3-羟基靛红。

儲存類別代碼

13 - Non Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

554.0 °F - closed cup

閃點(°C)

290 °C - closed cup

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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分析證明 (COA)

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Study of Creatinine and its 5-Alkoxy Analogs: Structure and Conformational Studies in the Solid and Solution States by X-Ray Crystallography, NMR, UV and Mass Spectrometry
Arakali AV, et al.
Nucleosides, nucleotides & nucleic acids, 16(12), 2193-2218 (1997)
A Simple Conversion of Creatinine to Creatol via Creatinine Chloroamine
Ienaga K, et al.
Australian Journal of Chemistry, 68(2), 248-253 (2015)
Karel G M Moons et al.
Annals of internal medicine, 162(1), W1-73 (2015-01-07)
The TRIPOD (Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis) Statement includes a 22-item checklist, which aims to improve the reporting of studies developing, validating, or updating a prediction model, whether for diagnostic or prognostic purposes.
Richard E Gilbert et al.
Diabetologia, 57(7), 1325-1331 (2014-04-29)
As glycaemia and the incidence of microvascular diabetes complications follow a log-linear relationship, it becomes increasingly difficult to demonstrate a microvascular benefit of glucose-lowering when the HbA1c level is close to normal. The Outcome Reduction with an Initial Glargine Intervention
Norishige Yoshikawa et al.
Kidney international, 87(1), 225-232 (2014-07-24)
In this multicenter, open-label, randomized controlled trial, we determined whether 2-month prednisolone therapy for steroid-sensitive nephrotic syndrome was inferior or not to 6-month therapy despite significantly less steroid exposure. The primary end point was time from start of initial treatment

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