C4428

Cathepsin G from human leukocytes

lyophilized powder, ≥60 units/mg protein (Bradford)

• CAS號碼: 107200-92-0
• 酶委員會編號: 3.4.21.20 (BRENDA, IUBMB)
• MDL號碼: MFCD00130750
• 分類程式碼代碼: 12352200
• NACRES: NA.32

屬性

• 生物源: human leucocytes
• 品質等級: 200
• 形狀: lyophilized powder
• 比活性: ≥60 units/mg protein (Bradford)
• 分子量: 23-30 kDa
• UniProt登錄號: P08311
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• 基因資訊: human ... CTSG(1511)

描述

一般說明

Cathepsin G from human leukocytes is a neutral proteinase secreted by neutrophil granulocytes. It belongs to the family of serine proteases. Cathepsin G is a glycoprotein, which contains 1% carbohydrate. The gene is located on human chromosome 14q12.

應用

Cathepsin G from human leukocytes has been used to determine protease sensitivity. It has also been used for the stimulation and staining of dendritic cells and macrophage.

生化／生理作用

Cathepsin G from human leukocytes degrades various proteins, such as elastin, collagen, fibrinogen and immunoglobin. It may be implicated in muscle catabolism. Cathepsin G is involved in the activation or inactivation of protein hormones and the inactivation of plasma proteinase inhibitors. It alters the cytoskeleton, enhances the permeability of vascular endothelial cells and the chemotaxis of inflammatory cells. Cathepsin G is associated with autoimmunity and cancer. It exhibits chymotrypsin and trypsin like activity. Cathepsin G modulates neutrophil effector functions.

Cathepsin G has pro-apoptotic activity and can activate caspases in vitro.

單位定義

One unit will release one nanomole of p-nitroaniline per second from N-succinyl-Ala-Ala-Pro-Phe p-nitroanilide at pH 7.5 at 37 °C.

外觀

Lyophilized from 0.5 M pyridinium acetate, pH 5.3.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable