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About This Item
經驗公式（希爾表示法）:
C16H14ClN5NaO6PS
CAS號碼:
分子量：:
493.79
EC號碼:
MDL號碼:
分類程式碼代碼:
41106305
PubChem物質ID:
NACRES:
NA.77
推薦產品
品質等級
化驗
≥97.0% (HPLC)
形狀
powder
顏色
white
溶解度
H2O: 25 mg/mL
儲存溫度
−20°C
SMILES 字串
[Na+].Nc1ncnc2n([C@@H]3O[C@@H]4COP([O-])(=O)O[C@H]4[C@H]3O)c(Sc5ccc(Cl)cc5)nc12
InChI
1S/C16H15ClN5O6PS.Na/c17-7-1-3-8(4-2-7)30-16-21-10-13(18)19-6-20-14(10)22(16)15-11(23)12-9(27-15)5-26-29(24,25)28-12;/h1-4,6,9,11-12,15,23H,5H2,(H,24,25)(H2,18,19,20);/q;+1/p-1/t9-,11-,12-,15-;/m1./s1
InChI 密鑰
YIJFVHMIFGLKQL-DNBRLMRSSA-M
基因資訊
human ... PRKAR1A(5573) , PRKAR1AP(5574) , PRKAR1B(5575) , PRKAR2A(5576) , PRKAR2B(5577)
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相關類別
應用
8-（4-硫代氯苯基）腺苷3′5′-环状-单磷酸钠盐用于：
- 上调细胞胆固醇泵（三磷酸腺苷（ATP）结合盒（ABC）转运蛋白1，ABCA-1）
- 葡萄糖生成测定
- 刺激气道上皮细胞的囊性纤维化跨膜传导调节因子（CFTR）通道
生化／生理作用
膜通透性 cAMP 类似物。用作 cAMP 依赖性蛋白激酶 (PKA) 的选择性激活剂。抑制 cGMP 依赖性磷酸二酯酶，在较高浓度时，抑制 cAMP 依赖性磷酸二酯酶。抑制 n-甲酰-Met-Leu-Phe 刺激的磷酸肌醇水解和分泌，但不抑制白细胞中的血小板活化因子。使 HL-60 细胞更能抵抗 NO 诱导的 DNA 损伤。
特點和優勢
这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
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