557502

Ro-20-1724

≥98% (TLC), solid, cAMP phosphodiesterase inhibitor, Calbiochem

• 同義詞: Ro-20-1724, 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone
• 經驗公式（希爾表示法）: C₁₅H₂₂N₂O₃
• CAS號碼: 29925-17-5
• 分子量：: 278.35
• MDL號碼: MFCD00077397
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• product name: Ro-20-1724, A cell-permeable, selective inhibitor of cAMP-specific phosphodiesterase (PDE IV; IC₅₀ = 2 µM).
• 品質等級: 100
• 化驗: ≥98% (TLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze
• 顏色: white
• 溶解度: DMSO: 20%; ethanol: 4%
• 運輸包裝: ambient
• 儲存溫度: 10-30°C
• InChI: 1S/C15H22N2O3/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18)
• InChI 密鑰: PDMUULPVBYQBBK-UHFFFAOYSA-N

描述

一般說明

A cell-permeable, selective inhibitor of cAMP-specific phosphodiesterase (PDE IV; IC₅₀ = 2 µM). Inhibits superoxide generation and arachidonic-induced platelet aggregation. Also inhibits fMLP-induced neutrophil adhesion to vascular endothelial cells.

Selective inhibitor of cAMP-specific phosphodiesterase (PDE IV, IC₅₀ = 2 µM). Inhibits superoxide generation and arachidonic-induced platelet aggregation. Also inhibits fMLP-induced neutrophil adhesion to vascular endothelial cells.

生化／生理作用

Cell permeable: yes

Primary Target
PDE IV

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 2 µM against PDE IV

警告

Toxicity: Irritant (B)

其他說明

Derian, C.K., et al. 1995. J. Immunol. 154, 308.
Rubin, L.L., et al. 1991. J. Cell Biol.115, 1725.
Lad, P.M., et al. 1985. Biochim. Biophys. Acta 846, 286.
Bergstrand, H., et al. 1977. Mol. Pharmacol.13, 38.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable