C2917

Corticotropin Releasing Factor Antagonist

≥97% (HPLC)

• 同義詞: α-Helical CRF (9-41), α-Helical corticotropin releasing factor fragment (9-41)
• 經驗公式（希爾表示法）: C₁₆₆H₂₇₄N₄₆O₅₃S₂
• CAS號碼: 99658-03-4
• 分子量：: 3826.36
• MDL號碼: MFCD00081543
• 分類程式碼代碼: 51111800
• NACRES: NA.32

屬性

• 品質等級: 200
• 化驗: ≥97% (HPLC)
• 形狀: powder
• 儲存溫度: −20°C
• 基因資訊: human ... CRH(1392) ; mouse ... CRH(12918) ; rat ... CRH(81648)

描述

Amino Acid Sequence

Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Met-Leu-Glu-Met-Ala-Lys-Ala-Glu-Gln-Glu-Ala-Glu-Gln-Ala-Ala-Leu-Asn-Arg-Leu-Leu-Leu-Glu-Glu-Ala-NH2

生化／生理作用

Exhibits 10-fold higher affinity for rat CRF_2α receptors over human CRF_2α receptors.

The corticotropin releasing factor (CRF) antagonist α-helical CRF [9-41] exhibits 10-fold higher affinity for rat CRF_2α receptors over human CRF_2α receptors. It has been used to elucidate the role of CRF in various physiological systems. In colonic epithelium, it abolishes CRF-induced changes in ion secretion, and significantly inhibits CRF-stimulated conductance. It antagonizes the CRF-induced proinflammatory degranulation of perivascular mast cells that are activated in response to acute psychological stress and CRF secretion.

其他說明

Lyophilized from 0.1% TFA in H2O

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)