推薦產品
產品名稱
缺氧诱导因子羟化酶抑制剂，DMOG, The HIF-Hydroxylase Inhibitor, DMOG, also referenced under CAS 89464-63-1, controls the biological activity of HIF-Hydroxylase. This small molecule/inhibitor is primarily used for Cell Structure applications.
品質等級
化驗
≥98% (HPLC)
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
desiccated (hygroscopic)
顏色
pink-white to peach-white
溶解度
DMSO: 50 mg/mL
運輸包裝
ambient
儲存溫度
2-8°C
SMILES 字串
N(CC(=O)OC)C(=O)C(=O)OC
InChI
1S/C6H9NO5/c1-11-4(8)3-7-5(9)6(10)12-2/h3H2,1-2H3,(H,7,9)
InChI 密鑰
BNJOZDZCRHCODO-UHFFFAOYSA-N
一般說明
一种可渗透细胞的2-OG（2-氧戊二酸酯）类似物，有望作为所有2-OG依赖性双加氧酶的竞争性抑制剂。通过抑制HIF-PH-（HIF-α-脯氨酰羟化酶）催化的ODD（氧依赖性降解域）脯氨酰羟化（分别为HIF-1α和HIF-2α中的Pro564和Pro530）和天冬氨酰/天冬氨酰β羟化酶催化的CAD Asp羟基化（分别为HIF-1α和HIF-2α中的Asn803和Asn851），有效上调常氧HIF-α转录活性（培养物中的有效浓度=1 mM），阻断pVHL（von Hippel-Lindau）泛素连接酶复合物介导的HIF-α降解，同时促进HIF CAD（COOH末端激活域）p300/CBP关联性。还证明，DMOG可增强鼠体内缺血模型肌肉组织中动脉结扎诱导的HIF-1α和FLK的上调（在11天内分别上调100%和40%；8 mg/0.5 ml/动物/腹膜内；q.o.d.）。
警告
毒性：标准处理（A）
重構
复溶后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。
其他說明
Pollard, P.J., et al. 2008.Biochem.J.416, 387.
Chen, H., et al. 2006.Cancer Res.66, 9009.
Milkiewicz, M., et al. 2004.J. Physiol.560, 21.
Lando, D., et al. 2002.Science295, 858.
Jaakkola, P., et al. 2001.Science292, 468.
Chen, H., et al. 2006.Cancer Res.66, 9009.
Milkiewicz, M., et al. 2004.J. Physiol.560, 21.
Lando, D., et al. 2002.Science295, 858.
Jaakkola, P., et al. 2001.Science292, 468.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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