C3042

Corticotropin Releasing Factor human, rat

≥95% (HPLC), powder

• 同義詞: CRF, CRH
• 經驗公式（希爾表示法）: C₂₀₈H₃₄₄N₆₀O₆₃S₂
• CAS號碼: 86784-80-7
• 分子量：: 4757.45
• MDL號碼: MFCD00213806
• 分類程式碼代碼: 12352200
• NACRES: NA.32

屬性

• 生物源: human; rat
• 品質等級: 200
• 化驗: ≥95% (HPLC)
• 形狀: powder
• 分子量: 4757.45
• 儲存條件: (Keep container tightly closed in a dry and well-ventilated place)
• 技術: activity assay: suitable
• 溶解度: water: 1.00-1.04 mg/mL, colorless
• UniProt登錄號: P06850
• 儲存溫度: −20°C
• InChI 密鑰: VXFVFWFSJFSXHN-FAUHKOHMSA-N
• 基因資訊: human ... CRH(1392)

描述

Amino Acid Sequence

Ser-Glu-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Met-Glu-Ile-Ile-NH2

一般說明

The corticotropin-releasing factor is a 41-amino-acid polypeptide. It is expressed in neurons, the hypothalamus, and the amygdala.

Research area: Neuroscience

應用

Corticotropin Releasing Factor human, rat has been used:

• as a component in Dulbecco′s modified eagle medium (DMEM) for incubating lung explants
• as a component in serum-free complete medium for isolation and culturing of fetal distal lung epithelial cells
• in the synthesis of the corticotropin-releasing factor(CRF)-TAMRA 1 mixture
• in chronic intracerebroventicular administration, to study its effect on hypoxia in hippocampus

生化／生理作用

CRF is a hypothalamic peptide that releases ACTH and endorphin from the anterior pituitary. It is also a neurotransmitter in the central nervous system, and is involved in autonomic and endocrine responses to stress.

Corticotropin-releasing factor modulates stress responses. It facilitates stress-stimulated activation of the hypothalamic−pituitary−adrenal system.Corticotropin Releasing Factor/hormone (CRF/H) at higher levels has been observed in stress-related physiological and behavioral disorders. It has been involved in anxiety and depression disorders. Under stress conditions, the release of CRH activates the corticotrophin-releasing hormone receptor type I (CRHR1) in the anterior pituitary for the release of adrenocorticotropic hormone (ACTH) that further stimulates the production/secretion of cortisol/corticosterone.

Releases ACTH and endorphin from the anterior pituitary; central nervous system neurotransmitter.

其他說明

Lyophilized from 0.1% TFA in H2O

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)