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Key Documents

B4056

Sigma-Aldrich

Bisindolylmaleimide XI hydrochloride

≥98% (TLC), solid

同義詞:

Ro 32-0432

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About This Item

經驗公式(希爾表示法):
C28H28N4O2 · HCl
分子量::
489.01
MDL號碼:
分類程式碼代碼:
12352111
PubChem物質ID:
NACRES:
NA.77

品質等級

化驗

≥98% (TLC)

形狀

solid

溶解度

DMSO: soluble

儲存溫度

−20°C

SMILES 字串

Cl.CN(C)CC1CCn2c(C1)cc3ccc(cc23)C4=C(C(=O)NC4=O)c5cn(C)c6ccccc56

InChI

1S/C28H28N4O2.ClH/c1-30(2)15-17-10-11-32-20(12-17)13-18-8-9-19(14-24(18)32)25-26(28(34)29-27(25)33)22-16-31(3)23-7-5-4-6-21(22)23;/h4-9,13-14,16-17H,10-12,15H2,1-3H3,(H,29,33,34);1H

InChI 密鑰

WMVQGKBSNAIMHI-UHFFFAOYSA-N

生化/生理作用

Selective inhibitor of protein kinase C.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析證明 (COA)

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Guillaume Robert et al.
PloS one, 4(11), e7889-e7889 (2009-11-20)
CML is an hematopoietic stem cell disease characterized by the t(9;22) (q34;q11) translocation encoding the oncoprotein p210BCR-ABL. The effect of acadesine (AICAR, 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside) a compound with known antileukemic effect on B cell chronic lymphoblastic leukemia (B-CLL) was investigated in different
Caline S Karam et al.
Journal of chemical neuroanatomy, 83-84, 91-98 (2017-06-03)
The dopamine transporter (DAT), which mediates the inactivation of released dopamine through its reuptake, is the primary molecular target for the actions of psychostimulants. An increasing number of studies support an essential role for phosphorylation of serines (Ser) in the
M Signore et al.
Cell death & disease, 5, e1223-e1223 (2014-05-09)
Glioblastoma (GBM) is the most common and deadly adult brain tumor. Despite aggressive surgery, radiation, and chemotherapy, the life expectancy of patients diagnosed with GBM is ∼14 months. The extremely aggressive nature of GBM results from glioblastoma stem-like cells (GSCs)
Florence P Varodayan et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(17), 4593-4603 (2017-04-02)
L-type voltage-gated calcium channels (LTCCs) are implicated in several psychiatric disorders that are comorbid with alcoholism and involve amygdala dysfunction. Within the amygdala, the central nucleus (CeA) is critical in acute alcohol's reinforcing actions, and its dysregulation in human alcoholics
S Khom et al.
Science advances, 6(12), eaaz1050-eaaz1050 (2020-03-25)
Behavioral and clinical studies suggest a critical role of substance P (SP)/neurokinin-1 receptor (NK-1R) signaling in alcohol dependence. Here, we examined regulation of GABA transmission in the medial subdivision of the central amygdala (CeM) by the SP/NK-1R system, and its

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