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About This Item
經驗公式（希爾表示法）:
C12H11N5O
CAS號碼:
分子量：:
241.25
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
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![[2-[2-(2-甲氧基乙氧基)乙氧基]乙氧基]对甲苯磺酸酯 90%](/deepweb/assets/sigmaaldrich/product/structures/246/083/be709a40-d1eb-4e98-9c26-c8c14e998696/640/be709a40-d1eb-4e98-9c26-c8c14e998696.png)
品質等級
化驗
≥98% (TLC)
形狀
solid
溶解度
methanol: 20 mg/mL
儲存溫度
room temp
SMILES 字串
Nc1nc(OCc2ccccc2)c3nc[nH]c3n1
InChI
1S/C12H11N5O/c13-12-16-10-9(14-7-15-10)11(17-12)18-6-8-4-2-1-3-5-8/h1-5,7H,6H2,(H3,13,14,15,16,17)
InChI 密鑰
KRWMERLEINMZFT-UHFFFAOYSA-N
基因資訊
human ... MGMT(4255)
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應用
使用O6-苄基鸟嘌呤：
- 用作胶质母细胞瘤干细胞中甲基鸟嘌呤甲基转移酶(MGMT)抑制剂
- 在N-乙基-N-亚硝基脲(ENU)疗法之前用作胚胎干细胞中的O6-烷基鸟嘌呤-烷基转移酶(AGT)的酶抑制剂
- 在HL-60人早幼粒白血病生长抑制试验中AGT的抑制剂
生化／生理作用
O6-苄基鸟嘌呤(O6BG)可通过苄基转移阻断活性部位来抑制甲基鸟嘌呤甲基转移酶(MGMT)。使用O6BG与双氯乙基亚硝基脲(BCNU)或卡莫司汀治疗包括淋巴瘤、黑色素瘤和肉瘤等实体肿瘤是有效的。
O(6)-苄基鸟嘌呤是一种抗肿瘤剂，它通过与DNA修复酶O(6)-烷基鸟嘌呤DNA烷基转移酶（AGT）结合，抑制AGT介导的DNA修复。它被广泛用于各种DNA修复机制研究，并且可加强其他破坏DNA的化疗药物的作用。
訊號詞
Warning
危險分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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