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H1753

Sigma-Aldrich

肼屈嗪 盐酸盐

同義詞:

1-肼基二氮杂萘 盐酸盐

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About This Item

經驗公式(希爾表示法):
C8H8N4 · HCl
CAS號碼:
分子量::
196.64
EC號碼:
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

生物源

synthetic (organic)

化驗

≥99% (TLC)

形狀

powder

mp

273 °C

溶解度

water: 50 mg/mL

SMILES 字串

Cl[H].N\N=C1/N=NC=C2C=CC=CC12

InChI

1S/C8H8N4.ClH/c9-11-8-7-4-2-1-3-6(7)5-10-12-8;/h1-5,7H,9H2;1H/b11-8-;

InChI 密鑰

SECXUXOCDLQOBI-MKFZHGHUSA-N

基因資訊

尋找類似的產品? 前往 產品比較指南

應用

盐酸肼屈嗪已用于:
  • 研究其作为血管扩张药,对大鼠幼鼠T细胞频率升高相关高血压的影响
  • 研究其作为氨基脲敏感性胺氧化酶(SSAO)抑制剂,对心肌缺血再灌注(I/R)损伤的影响
  • 研究其作为血管扩张药,对胰岛素分泌和葡萄糖耐受的影响

生化/生理作用

盐酸肼屈嗪(Hydralazine)可用于治疗心力衰竭和高血压。
抑制DNA甲基转移酶并调节基因表达的表观遗传调控。非选择性MAO-A/B抑制剂;降压药;氨基脲敏感性胺氧化酶抑制剂。

特點和優勢

该化合物收录于受体分类和信号转导手册的《多巴胺和去甲肾上腺素代谢》页面。想要浏览手册的其他页面, 请单击此处

象形圖

Skull and crossbones

訊號詞

Danger

危險分類

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


分析證明 (COA)

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Mahesh P Kate et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 34(1), 81-86 (2013-09-21)
Blood pressure (BP) reduction after intracerebral hemorrhage (ICH) is controversial, because of concerns that this may cause critical reductions in perihematoma perfusion and thereby precipitate tissue damage. We tested the hypothesis that BP reduction reduces perihematoma tissue oxygenation.Acute ICH patients
Philip C Burcham et al.
Molecular pharmacology, 82(5), 876-886 (2012-08-08)
Toxic carbonyls such as acrolein participate in many degenerative diseases. Although the nucleophilic vasodilatory drug hydralazine readily traps such species under "test-tube" conditions, whether these reactions adequately explain its efficacy in animal models of carbonyl-mediated disease is uncertain. We have
Ashley D Hunt et al.
The Journal of organic chemistry, 78(17), 8847-8852 (2013-07-31)
Azomethine imines can be accessed upon heating appropriate alkynylhydrazide precursors. This simple thermal hydroamination approach allows the formation of five- and six-membered dipoles in modest to excellent yields. The structure of the acyl group is important to minimize side reactions
Dirk Westermann et al.
Basic research in cardiology, 107(6), 308-308 (2012-11-03)
Sildenafil inhibits cyclic GMP-specific phosphodiesterase type-5A (PDE5A) and can prevent cardiac hypertrophy and left ventricular (LV) dysfunction in mice subjected to severe pressure-overload. The pathophysiological role of sildenafil in adverse remodeling in the hypertensive heart after chronic renin-angiotensin aldosterone system
Nadine S Sauter et al.
Diabetes, 64(4), 1273-1283 (2014-10-30)
Pathological activation of the renin-angiotensin system (RAS) is associated with the metabolic syndrome, and the new onset of type 2 diabetes can be delayed by RAS inhibition. In animal models of type 2 diabetes, inhibition of the RAS improves insulin

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