跳轉至內容
Merck
全部照片(3)

Key Documents

A8003

Sigma-Aldrich

别嘌醇

xanthine oxidase inhibitor

同義詞:

1H-吡唑并 (3,4-d) 嘧啶-4-醇, 4-羟基吡唑并 (3,4-d) 嘧啶, 4-羟基吡唑并 [3,4-d] 嘧啶, HPP

登入查看組織和合約定價


About This Item

經驗公式(希爾表示法):
C5H4N4O
CAS號碼:
分子量::
136.11
EC號碼:
MDL號碼:
分類程式碼代碼:
12352202
PubChem物質ID:
NACRES:
NA.77

生物源

synthetic (organic)

品質等級

化驗

≥99% (TLC)

形狀

powder

mp

>300 °C (lit.)

溶解度

1 M NaOH: soluble 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow

儲存溫度

room temp

SMILES 字串

O=C1NC=Nc2[nH]ncc12

InChI

1S/C5H4N4O/c10-5-3-1-8-9-4(3)6-2-7-5/h1-2H,(H2,6,7,8,9,10)

InChI 密鑰

OFCNXPDARWKPPY-UHFFFAOYSA-N

基因資訊

human ... XDH(7498)

尋找類似的產品? 前往 產品比較指南

應用

别嘌呤醇已用于:
  • 降低尿酸浓度,研究其对小鼠肾损伤和炎症的疗效
  • 作为黄嘌呤氧化酶抑制剂,检测杀白细胞素(PVL)中性粒细胞胞外诱捕网(NETosis)对人多形核细胞(hPMN)不同酶、通道或细胞器的依赖性
  • 作为参考标准品,体外研究橄榄叶组分对黄嘌呤氧化酶的抑制作用

别嘌呤醇适合:
  • 静脉注射小鼠抑制黄嘌呤氧化酶
  • 用作黄嘌呤氧化酶抑制剂
  • 用作黄嘌呤氧化酶抑制试验的阳性对照
  • 制备威斯康星大学保存液,用于在猪胰岛纯化中保持渗透压稳定,增强胰岛和胰腺泡片段的密度差异

生化/生理作用

别嘌呤醇是一种嘌呤类似物,可抑制某些参与嘌呤代谢的酶。减少体内的尿酸合成。别嘌呤醇可抑制黄嘌呤氧化酶,对动脉粥样硬化、急性肺损伤和充血性心力衰竭具有抗炎作用。
黄嘌呤氧化酶和初始嘧啶生物合成的抑制剂。治疗高尿酸血症和痛风的经典药物。

象形圖

Skull and crossbones

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 3 Oral - Skin Sens. 1

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號,寫有 ‘Lot’或‘Batch’.。

已經擁有該產品?

您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

Nitrate partially inhibits lipopolysaccharide-induced inflammation by maintaining mitochondrial function.
Yang Yang et al.
The Journal of international medical research, 48(2), 300060520902605-300060520902605 (2020-02-12)
H Kubo et al.
The Journal of clinical investigation, 97(11), 2680-2684 (1996-06-01)
Mice with chronic granulomatous disease (X-CGD mice) generated by mutating the X-linked gene for a subunit of NADPH oxidase have been analyzed for their ability to respond to intravenous injection of purified cobra venom factor (CVF). This agent in wild-type
Michael P M van der Burg et al.
TheScientificWorldJournal, 3, 1154-1159 (2003-12-04)
Generally, prior to the purification of isolated pancreatic islets, the collagenase-digested tissue is incubated in the University of Wisconsin solution (UWS; approximately 320 mOsm) for osmotic stabilization to preserve or improve the density differences between islets and acinar fragments. The
Sarah Leighton et al.
Experimental dermatology, 22(3), 189-194 (2013-02-08)
Exposure to solar ultraviolet (UV) radiation suppresses adaptive immune responses. This contributes to skin carcinogenesis but may protect from some autoimmune diseases. However, the molecular changes occurring within UV-exposed skin that precipitate the downstream events leading to immune suppression are
Cytochemical localization of H2O2 in biological tissues.
E Ann Ellis et al.
Methods in molecular biology (Clifton, N.J.), 196, 3-12 (2002-08-03)

我們的科學家團隊在所有研究領域都有豐富的經驗,包括生命科學、材料科學、化學合成、色譜、分析等.

聯絡技術服務