A8001

乌头碱

≥95% (HPLC), crystalline

• 同義詞: 乙酰苯甲酰阿康碱
• 經驗公式（希爾表示法）: C₃₄H₄₇NO₁₁
• CAS號碼: 302-27-2
• 分子量：: 645.74
• Beilstein: 74608
• EC號碼: 206-121-7
• MDL號碼: MFCD00082375
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24891304
• NACRES: NA.77

屬性

• 品質等級: 200
• 化驗: ≥95% (HPLC)
• 形狀: crystalline
• 顏色: white
• 溶解度: H₂O: 0.3 mg/mL; ethanol: 35 mg/mL
• SMILES 字串: CCN1C[C@]2(COC)[C@H](O)C[C@@H](OC)C34C5C[C@]6(O)[C@@H](OC)[C@H](O)[C@@](OC(C)=O)(C5[C@H]6OC(=O)c7ccccc7)C([C@H](OC)C23)C14
• InChI: 1S/C34H47NO11/c1-7-35-15-31(16-41-3)20(37)13-21(42-4)33-19-14-32(40)28(45-30(39)18-11-9-8-10-12-18)22(19)34(46-17(2)36,27(38)29(32)44-6)23(26(33)35)24(43-5)25(31)33/h8-12,19-29,37-38,40H,7,13-16H2,1-6H3/t19-,20-,21-,22-,23+,24+,25?,26?,27+,28-,29+,31+,32-,33?,34-/m1/s1
• InChI 密鑰: XFSBVAOIAHNAPC-VBUFWTEXSA-N

描述

應用

Aconitine has been used:

• to study its cardiotoxic effects along the pericardium meridian (PM) on cardiac rhythm in rabbits
• as a standard in high-performance thin layer chromatography (HPTLC) fingerprinting method
• in the aconitine-based lipo-alkaloids semi-synthesis

Aconitine is a neurotoxin which activates tetrodotoxin-sensitive Na⁺ channels, inducing presynaptic depolarization and blocking the release of neurotransmitters. Aconitine also blocks norepinephrine reuptake. In the heart, aconitine induces ventricular tachycardia after intracoronary injection.

生化／生理作用

Aconitine is a diesterditerpene alkaloid found abundantly in the plant Aconitum genera. It possesses analgesic, antipyretic and antirheumatic activity. Aconitine is involved in blocking neurotransmission. It acts as a neurotoxin as well as a cardiotoxin. Aconitine triggers ventricular tachycardia (VT) and ventricular fibrillation (VF). It interacts with voltage-dependent Na⁺ channels which results in the depolarization of membranes. Aconitine may exhibit therapeutic effects against systemic lupus erythematosus (SLE). It also inhibits the reuptake of norepinephrine.

Neurotoxin. Activates tetrodotoxin-sensitive Na⁺ channels, inducing presynaptic depolarization, thus blocking the nerve action potential which, in turn, blocks the release of neurotransmitters and decreases the end plate potential at the neuromuscular junction. Aconitine also blocks norepinephrine reuptake. In the heart, aconitine induces ventricular tachycardia after intracoronary injection. In cultured ventricular myocytes, aconitine increases the duration of the action potential and induces the appearance of early after depolarization.

安全資訊

• 象形圖: GHS06
• 訊號詞: Danger
• 危險聲明: H300 + H330
• 防範說明: P260 - P264 - P271 - P284 - P304 + P340 + P310 - P403 + P233
• 危險分類: Acute Tox. 1 Oral - Acute Tox. 2 Inhalation
• 儲存類別代碼: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges