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A3109

Sigma-Aldrich

A-803467

≥98% (HPLC)

同義詞:

5-(4-氯苯基)-N-(3,5-二甲氧基苯基)呋喃-2-甲酰胺

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About This Item

經驗公式（希爾表示法）:
C19H16NO4Cl
CAS號碼:
944261-79-4
分子量：:
357.79
MDL號碼:
MFCD10574689
分類程式碼代碼:
12352200
PubChem物質ID:
329770815
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

顏色

white to tan

溶解度

DMSO: >10 mg/mL

起源

Abbott

儲存溫度

room temp

SMILES 字串

COc1cc(NC(=O)c2ccc(o2)-c3ccc(Cl)cc3)cc(OC)c1

InChI

1S/C19H16ClNO4/c1-23-15-9-14(10-16(11-15)24-2)21-19(22)18-8-7-17(25-18)12-3-5-13(20)6-4-12/h3-11H,1-2H3,(H,21,22)

InChI 密鑰

VHKBTPQDHDSBSP-UHFFFAOYSA-N

一般說明

A-803467能够抑制感觉神经元的自发和诱发动作电位。它具有镇痛作用。A-803467能够在体内减少脊髓背角神经元的放电。
小分子A-803467是一种有效的选择性Nav1.8钠离子通道阻滞剂。Nav1.8是一种抗河豚毒素（TTX-R）钠离子通道，通过在周围感觉神经元中传递疼痛刺激而产生痛觉；A-803467通过阻滞该通道，能够对多种模型产生不同程度的疼痛减轻作用。 A-803467已被用于进一步探究Nav1.8在传递疼痛刺激中的作用，也可用作镇痛药。

生化／生理作用

A-803467能够在半数最大无活性和静止状态下阻断Nav1.8，IC50分别为 8 nM和79 nM。A-803467对Nav1.8的选择性比人类Nav1.2、1.3、1.5和1.7高100倍。

特點和優勢

该化合物由Abbott开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。

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