PZ0274

PF-01247324

≥98% (HPLC)

• 同義詞: 6-Amino-5-(2,3,5-trichlorophenyl)pyridine-2-carboxylic acid methylamide, 6-Amino-N-methyl-5-(2,3,5-trichlorophenyl)-2-Pyridinecarboxamide, N-Methyl-6-amino-5-(2,3,5-trichlorophenyl)pyridine-2-carboxamide, PF 01247324, PF-1247324
• 經驗公式（希爾表示法）: C₁₃H₁₀Cl₃N₃O
• CAS號碼: 875051-72-2
• 分子量：: 330.60
• 分類程式碼代碼: 41121801
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: DMSO: 20 mg/mL, clear
• 儲存溫度: room temp
• SMILES 字串: Clc1c(cc(cc1c2c(nc(cc2)C(=O)NC)N)Cl)Cl
• InChI: 1S/C13H10Cl3N3O/c1-18-13(20)10-3-2-7(12(17)19-10)8-4-6(14)5-9(15)11(8)16/h2-5H,1H3,(H2,17,19)(H,18,20)
• InChI 密鑰: HPIUHDCRVYDAEJ-UHFFFAOYSA-N

描述

生化／生理作用

In humans, PF-01247324 [6-amino-5-(2, 3, 5-trichloro-phenyl)-pyridine-2-carboxylic acid methylamide] prevents native tetrodotoxin-resistant (TTX-R) currents in dorsal root ganglion (DRG) neurons.

PF-01247324 is an orally bioavailable, selective and potent NaV1.8 channel blocker that inhibits that exhibits analgesic efficacy in rodent behavioral models of pain.

安全資訊

• 象形圖: GHS06
• 訊號詞: Danger
• 危險聲明: H301,H315,H319,H335
• 防範說明: P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
• 危險分類: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable