跳轉至內容
Merck
全部照片(2)

Key Documents

A6671

Sigma-Aldrich

放线酰胺素

≥98% (TLC), powder, leucine aminopeptidase inhibitor

同義詞:

3-[[1-[(2-(羟甲基)-1-吡咯烷基)羰基]-2-甲基苯基]氨基甲酰基]辛异羟肟酸

登入查看組織和合約定價


About This Item

經驗公式(希爾表示法):
C19H35N3O5
CAS號碼:
分子量::
385.50
Beilstein:
1555250
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

product name

放线酰胺素,

生物源

synthetic (organic)

化驗

≥98% (TLC)

形狀

powder

溶解度

ethanol: 50 mg/mL, clear, colorless

抗生素活性譜

Gram-negative bacteria
Gram-positive bacteria

作用方式

enzyme | inhibits

儲存溫度

−20°C

SMILES 字串

CCCCCC(CC(=O)NO)C(=O)NC(C(C)C)C(=O)N1CCCC1CO

InChI

1S/C19H35N3O5/c1-4-5-6-8-14(11-16(24)21-27)18(25)20-17(13(2)3)19(26)22-10-7-9-15(22)12-23/h13-15,17,23,27H,4-12H2,1-3H3,(H,20,25)(H,21,24)

InChI 密鑰

XJLATMLVMSFZBN-UHFFFAOYSA-N

尋找類似的產品? 前往 產品比較指南

一般說明

化学结构:肽

應用

放线酰胺素已被用作抑制C57BL/6小鼠中meprinβ活性的对照。它还已用于通过15N NMR波谱和等温滴定研究EcPDF与放线酰胺素的高亲和力交互效应。

生化/生理作用

放线酰胺素对肽脱甲酰基酶(PDF)具有抑制作用。对革兰氏阳性和苛养型革兰氏阴性微生物有效。
放线酰胺素是亮氨酸氨基肽酶的抑制剂。 放线酰胺素还被用于改善抗菌活性和抗肥胖疗法。

特點和優勢

该化合物是受体分类及信号转导手册上神经肽酶页面上的特色化合物。想要浏览手册的其他页面, 请单击此处

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號,寫有 ‘Lot’或‘Batch’.。

已經擁有該產品?

您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

Sonia Fieulaine et al.
PLoS biology, 9(5), e1001066-e1001066 (2011-06-02)
For several decades, molecular recognition has been considered one of the most fundamental processes in biochemistry. For enzymes, substrate binding is often coupled to conformational changes that alter the local environment of the active site to align the reactive groups
Ligand-induced changes in the structure and dynamics of Escherichia coli peptide deformylase
Amero CD, et al.
Biochemistry, 48(32), 7595-7607 (2009)
Diana Mader et al.
Microbes and infection, 12(5), 415-419 (2010-02-17)
The biosynthesis of proteins with N-terminal formylated methionine residues and subsequent protein deformylation are unique and invariant bacterial processes. They are exploited by the capacity of the human innate immune system to sense formylated peptides (FPs) and targeted by the
Asmaa Sina et al.
Cancer letters, 279(2), 171-176 (2009-03-07)
Recent profiling has identified the aminopeptidase N/CD13 inhibitor actinonin as a selective soluble secreted matrix metalloproteinase (MMP) inhibitor. Given that actinonin's effects against membrane-bound MMPs remain unknown and that MT1-MMP has been linked to chemo- and radio-therapy resistance in brain
Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor
Chen DZ, et al.
Biochemistry, 39(6), 1256-1262 (2000)

我們的科學家團隊在所有研究領域都有豐富的經驗,包括生命科學、材料科學、化學合成、色譜、分析等.

聯絡技術服務