A1276

Amastatin hydrochloride hydrate

powder, ≥97% (HPLC)

• 同義詞: (2S,3R)-3-Amino-2-hydroxy-5-methylhexanoyl-Val-Val-Asp hydrochloride hydrate
• 經驗公式（希爾表示法）: C₂₁H₃₈N₄O₈ · HCl · xH₂O
• CAS號碼: 100938-10-1
• 分子量：: 511.01 (anhydrous basis)
• Beilstein: 8888370
• MDL號碼: MFCD00150636
• 分類程式碼代碼: 12352202
• PubChem物質ID: 24890521
• NACRES: NA.77

屬性

• 產品名稱: Amastatin hydrochloride hydrate, ≥97% (HPLC)
• 生物源: synthetic (organic)
• 品質等級: 200
• 化驗: ≥97% (HPLC)
• 形狀: powder
• mp: 202-205 °C
• 溶解度: methanol: 1 mM (Stock solution stable for 1 month at −20 °C. Working solution stable for 1 day.)
• 抗生素活性譜: neoplastics
• 作用方式: enzyme | inhibits
• 儲存溫度: −20°C
• SMILES 字串: Cl[H].[H]O[H].CC(C)C[C@@H](N)[C@H](O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(O)=O
• InChI: 1S/C21H38N4O8.ClH.H2O/c1-9(2)7-12(22)17(28)20(31)25-16(11(5)6)19(30)24-15(10(3)4)18(29)23-13(21(32)33)8-14(26)27;;/h9-13,15-17,28H,7-8,22H2,1-6H3,(H,23,29)(H,24,30)(H,25,31)(H,26,27)(H,32,33);1H;1H2/t12-,13+,15+,16+,17+;;/m1../s1
• InChI 密鑰: WBYDQJQQTMJMQH-AFROIDPFSA-N

描述

一般說明

Chemical structure: peptide

生化／生理作用

Amastatin is a slow, tight-binding inhibitor of aminopeptidases. It inhibits cytosolic leucine aminopeptidase (EC.3.4.11.1), microsomal aminopeptidase M (EC.3.4.11.2) and bacterial leucine aminopeptidase (EC.3.4.11.10). It is less effective against aminopeptidase A (EC 3.4.11.7), the enzyme that converts Angiotensin II to Angiotensin III. Effective concentration: 1-10 μM.

It inhibits cytosolic leucine aminopeptidase (EC.3.4.11.1), microsomal aminopeptidase M (EC.3.4.11.2) and bacterial leucine aminopeptidase (EC.3.4.11.10). It is less effective against aminopeptidase A (EC 3.4.11.7), the enzyme that converts angiotensin II to angiotensin III. Potentiates the CNS effects of vasopressin and oxytocin in vivo.

Effective concentration: 1-10 μM.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)