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Merck
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Key Documents

282M-9

Sigma-Aldrich

HMB-45 (HMB-45) Mouse Monoclonal Antibody

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

mouse

品質等級

100
500

共軛

unconjugated

抗體表格

culture supernatant

抗體產品種類

primary antibodies

無性繁殖

HMB-45, monoclonal

描述

For In Vitro Diagnostic Use in Select Regions (See Chart)

形狀

buffered aqueous solution

物種活性

human

包裝

vial of 0.1 mL concentrate (282M-94)
vial of 0.5 mL concentrate (282M-95)
bottle of 1.0 mL predilute (282M-97)
vial of 1.0 mL concentrate (282M-96)
bottle of 7.0 mL predilute (282M-98)

製造商／商標名

Cell Marque™

技術

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

同型

IgG1κ

控制

melanoma

運輸包裝

wet ice

儲存溫度

2-8°C

視覺化

cytoplasmic

一般說明

Anti-HMB45 is a useful melanoma immunohistochemical marker that reacts with antigenspresent on immature melanosomes. Anti-HMB45 is useful for identifying amelanoticmelanoma from other neoplastic lesions with similar morphology.

品質


IVD
IVD
IVD
RUO

聯結

HMB-45 Positive Control Slides, Product No. 282S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

外觀

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

準備報告

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

其他說明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律資訊

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Helene Nortvig Abrahamsen et al.
Cancer, 100(8), 1683-1691 (2004-04-10)
The optimal technique for sentinel lymph node (SN) assessment in patients with melanoma is controversial. Molecular analysis (reverse transcriptase-polymerase chain reaction) detects significantly greater numbers of SNs with suspected micrometastases (up to 71%) than does routine histopathology (approximately 20%). The
M R Wick et al.
Archives of pathology & laboratory medicine, 112(6), 616-620 (1988-06-01)
The efficacy of two new monoclonal antibodies with cell lineage-restricted reactivity (HMB-45 [melanocytes] and anti-synaptophysin [neuroepithelial cells]) was compared with that of "traditional" antibody panels in the delineation of malignant melanoma (MM) of the sinonasal region, nasopharyngeal carcinoma (NPC), and
L Weiss et al.
The Journal of pathology, 150(3), 195-203 (1986-11-01)
The sequence of events in haematogenous metastasis from colonic carcinoma was analysed, using 1541 necropsy reports from 16 centres. The findings are consistent with the cascade hypothesis that metastases develop in discrete steps, first in the liver, next in the
An assessment of a melanoma-specific antibody (HMB-45) and other immunohistochemical markers of malignant in paraffin-embedded tissue.
AS-Y Leong, et al.
Surgical Pathology, 2, 137-145 (1989)
B L Baisden et al.
The American journal of surgical pathology, 24(8), 1140-1146 (2000-08-10)
Despite the profound therapeutic and prognostic implications of nodal metastases in patients with melanoma, there is no consensus strategy for the optimal detection of metastases in sentinel lymph node biopsies. Traditional microscopic examination may be too crude to detect scattered
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Immunohistochemistry (IHC) techniques and applications have greatly improved, dermatopathology is still largely based on H&E stained slides.This paper outlines ways in which IHC antibodies can be utilized for dermatopathology.

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A brief overview on diagnostic immunohistochemistry (IHC) and its importance in modern clinical pathology. Learn more about IHC and its role in cancer diagnosis and the detection of infectious diseases.

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