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Merck
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重要文件

383R-1

Sigma-Aldrich

SOX-10 (EP268) Rabbit Monoclonal Primary Antibody

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

品質等級

100
500

共軛

unconjugated

抗體表格

culture supernatant

抗體產品種類

primary antibodies

無性繁殖

EP268, monoclonal

描述

(For In Vitro Diagnostic Use in Select Regions (See Chart))

形狀

buffered aqueous solution

物種活性

human

包裝

vial of 0.1 mL concentrate (383R-14)
vial of 0.5 mL concentrate (383R-15)
bottle of 1.0 mL predilute (383R-17)
vial of 1.0 mL concentrate (383R-16)
bottle of 7.0 mL predilute (383R-18)

製造商／商標名

Cell Marque®

技術

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200

同型

IgG

控制

melanoma, skin melanocytes

運輸包裝

wet ice

儲存溫度

2-8°C

視覺化

nuclear

基因資訊

human ... SOX10(6663)

一般說明

Sry-related HMG-BOX gene 10, SOX-10, is a transcription factor involved in neural crest and peripheral nervous system development and acts as a nucleocytoplasmic shuttle protein. SOX-10 is expressed in melanocytic lineages and is a sensitive melanoma marker for conventional, and desmoplastic subtypes. In normal tissues, SOX-10 is expressed in melanocytes and myoepithelial cells.

品質


IVD
IVD
IVD
RUO

聯結

SOX-10 Positive Control Slides, Product No. 383S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

外觀

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

準備報告

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

其他說明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律資訊

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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分析證明 (COA)

Lot/Batch Number
0000284491
0000284491
1607702A-Z
1535117A-Z
1518301A-Z

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A Robson et al.
Histopathology, 38(2), 135-140 (2001-02-24)
The histological distinction of desmoplastic melanoma from cutaneous scar tissue, particularly in the context of re-excision specimens or possible recurrence, may be very difficult. Immunostaining for S100 protein is often used to discriminate although there are little data on S100
Joe A Chorny et al.
The American Journal of dermatopathology, 24(4), 309-312 (2002-07-27)
Distinguishing desmoplastic melanoma (DM) from scar tissue on routine microscopy can be difficult, especially in re-excision specimens, and S100 immunohistochemistry has been recommended as a useful adjunct. The purpose of this study is to evaluate the extent and nature of
Robert N Kelsh
BioEssays : news and reviews in molecular, cellular and developmental biology, 28(8), 788-798 (2006-08-24)
For both vertebrate developmental and evolutionary biologists, and also for clinicians, the neural crest (NC) is a fundamental cell population. An understanding of Sox10 function in NC development is of particular significance since Sox10 mutations underlie several neurocristopathies. Surprisingly, experiments
T A Longacre et al.
The American journal of surgical pathology, 20(12), 1489-1500 (1996-12-01)
The clinical, histologic, and immunohistologic features of 22 desmoplastic melanomas (DMM), 10 mixed desmoplastic and spindle-cell melanomas (DMM/SMM), and two cellular spindle-cell melanomas (SMM) were studied. Patients ranged in age from 35 to 91 years (mean, 67) and included 23
Daisuke Nonaka et al.
The American journal of surgical pathology, 32(9), 1291-1298 (2008-07-19)
S100 protein is a sensitive marker for melanomas and peripheral nerve sheath tumors. It is, however, expressed by other mesenchymal and epithelial tumors. Despite its low specificity, S100 protein is valuable for the diagnosis of desmoplastic melanomas and peripheral nerve
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Immunohistochemistry (IHC) techniques and applications have greatly improved, dermatopathology is still largely based on H&E stained slides.This paper outlines ways in which IHC antibodies can be utilized for dermatopathology.

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