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Merck
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重要文件

22640

Sigma-Aldrich

奎宁 半硫酸盐 一水合物

BioReagent, suitable for fluorescence, 99.0-101.0%

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About This Item

經驗公式(希爾表示法):
C20H24N2O2 · 0.5H2O4S · H2O
CAS號碼:
分子量::
391.47
Beilstein:
6113937
MDL號碼:
分類程式碼代碼:
12352210
PubChem物質ID:
NACRES:
NA.32

產品線

BioReagent

品質等級

化驗

99.0-101.0%

mp

~225 °C (dec.) (lit.)

螢光

λex 347 nm; λem 448 nm in 0.5 M sulfuric acid

適合性

suitable for fluorescence

抗生素活性譜

parasites

作用方式

enzyme | inhibits

SMILES 字串

O.O.OS(O)(=O)=O.COc1ccc2nccc([C@@H](O)C3CC4CCN3C[C@@H]4C=C)c2c1.COc5ccc6nccc([C@@H](O)C7CC8CCN7C[C@@H]8C=C)c6c5

InChI

1S/2C20H24N2O2.H2O4S.2H2O/c2*1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4;;/h2*3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4);2*1H2/t2*13-,14-,19-,20+;;;/m00.../s1

InChI 密鑰

ZHNFLHYOFXQIOW-LPYZJUEESA-N

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一般說明

Quinine hemisulfate salt monohydrate is a naturally occurring well known fluorescent standard material. Quinine hemisulfate salt monohydrate or QSM has a fluorescence lifetime between 1.0 to 3.0 ns.

應用

Quinine hemisulfate salt monohydrate is used for indirect photometric detection of polyamines in biological samples. It is suitable for studying metabolism of bio crystalized heme, hemozoin, in malarial parasites and to study the toxicity of heme (FP)-complexes.

生化/生理作用

钾通道阻滞剂。抗疟疾
钾通道阻滞剂。抗疟疾、抗胆碱能、抗高血压和降血糖剂;最初从南美树木的金鸡纳科中分离出来的生物碱。

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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Elaine B Bohórquez et al.
Malaria journal, 11, 350-350 (2012-10-24)
The naturally fluorescent compound quinine has long been used to treat malaria infections. Although some evidence suggests that quinine acts in the parasite food vacuole, the mechanism of action of quinine has not yet been resolved. The Plasmodium falciparum multidrug
Kira Behm et al.
Dalton transactions (Cambridge, England : 2003), 46(33), 10867-10875 (2017-08-02)
The synthesis, characterization, and fluorescence spectroscopy of E(C
Y Ma et al.
Journal of chromatography, 608(1-2), 93-96 (1992-09-11)
A rapid separation of polyamines and some related amino acids in cultured tumor cells by high-performance capillary zone electrophoresis with indirect photometric detection is demonstrated. 60 cm x 75 microns I.D. fused-silica capillary was used for the separation and quinine
S D Pack et al.
Optics letters, 23(15), 1215-1217 (2007-12-19)
We report on a novel laser-induced fluorescence triple-integration method (LIFTIME) that is capable of making rapid, continuous fluorescence lifetime measurements by a unique photon-counting technique. The LIFTIME has been convolved with picosecond time-resolved laser-induced fluorescence, which employs a high-repetition-rate mode-locked
F G Welsch et al.
ACS combinatorial science, 13(5), 518-529 (2011-08-13)
We describe here the results of a high throughput screening study for direct methanol fuel cell (DMFC) anode catalysts consisting of new elemental combinations with an optical high-throughput screening method, which allows the quantitative evaluation of the electrochemical activity of

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