Q1125

Quinine hydrochloride dihydrate

99-101% (titration), potassium channel blocker

• 經驗公式（希爾表示法）: C₂₀H₂₄N₂O₂ · HCl · 2H₂O
• CAS號碼: 6119-47-7
• 分子量：: 396.91
• EC號碼: 205-001-1
• MDL號碼: MFCD00078498
• 分類程式碼代碼: 12352210
• PubChem物質ID: 57654577
• NACRES: NA.77

屬性

• product name: Quinine hydrochloride dihydrate,
• 溶解度: H₂O: 0.25/5 g/mL, clear, colorless
• 抗生素活性譜: parasites
• 作用方式: enzyme | inhibits
• SMILES 字串: O.Cl.[H][C@]1(C[C@@H]2CC[N@H]1C[C@@H]2C=C)[C@H](O)c3ccnc4ccc(OC)cc34
• InChI: 1S/C20H24N2O2.ClH.H2O/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;;/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;1H;1H2/t13-,14-,19-,20+;;/m0../s1
• InChI 密鑰: SGVZDMWHXVXUBY-HZQSTTLBSA-N

描述

一般說明

Quinine is derived from the stem of cinchona (quina-quina) tree. It is an alkaloid having various applications in the field of medicine. Quinine is a basic compound with aryl amino alcohol group.

應用

Quinine hydrochloride dihydrate has been used in Drosophila larval behavioral assay. It has also been used in taste preference analysis among rats.

生化／生理作用

Quinine is widely used in the treatment of malaria. It possesses erythrocytic and gametocytocidal action against Plasmodium sp. It also serves as an analgesic drug. Upon administration, quinine is present mostly bound to α-1 acid glycoprotein in the body fluids. Quinine has the ability to cross the placenta and the blood brain barrier. It has a half-life of 11-18 hours. Tinnitus, hearing defects, nausea and headache are some of its side effects.

钾通道阻断剂。

安全資訊

• 象形圖: GHS08,GHS07
• 訊號詞: Danger
• 危險聲明: H302,H317,H334
• 防範說明: P261 - P264 - P272 - P280 - P301 + P312 - P302 + P352
• 危險分類: Acute Tox. 4 Oral - Resp. Sens. 1 - Skin Sens. 1
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Faceshields, Gloves