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Merck
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重要文件

22244

Sigma-Aldrich

神经酰胺 来源于牛脊髓

≥98.0% (TLC)

同義詞:

牛脊髓神经酰胺

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About This Item

MDL號碼:
分類程式碼代碼:
12352211
NACRES:
NA.25

生物源

bovine spinal cord

品質等級

化驗

≥98.0% (TLC)

形狀

solid

雜質

α-hydroxy fatty acids

溶解度

chloroform/methanol (99:1): 20 mg/mL, clear, colorless

脂質類型

sphingolipids

運輸包裝

wet ice

儲存溫度

−20°C

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應用

神经酰胺用于研究其对程序性细胞死亡(细胞凋亡)以及胰岛素信号传导的影响。

生化/生理作用

神经酰胺是细胞膜的次要成分。激活非典型蛋白激酶 C(例如 PKCzeta)

準備報告

通过以下报道改进的实验方案从脑苷脂中提取:H.E.。Carter et al., J. Lipid Res. 2, 228 (1961)

其他說明

销售限制可能适用

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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In the amyloidogenic pathway associated with Alzheimer disease (AD), the amyloid precursor protein (APP) is cleaved by β-secretase to generate a 99-aa C-terminal fragment (C99) that is then cleaved by γ-secretase to generate the β-amyloid (Aβ) found in senile plaques.

文章

Oxidative stress is mediated, in part, by reactive oxygen species produced by multiple cellular processes and controlled by cellular antioxidant mechanisms such as enzymatic scavengers or antioxidant modulators. Free radicals, such as reactive oxygen species, cause cellular damage via cellular.

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