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重要文件

Y0001587

托莫西汀杂质A

European Pharmacopoeia (EP) Reference Standard

同義詞:

R)-托莫西汀 盐酸盐, 盐酸托莫西汀 盐酸盐, (R)-N-甲基-γ-(2-甲基­苯氧基)苯丙胺 盐酸盐

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About This Item

經驗公式(希爾表示法):
C17H21NO · HCl
CAS號碼:
分子量::
291.82
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.24

等級

pharmaceutical primary standard

API 家族

atomoxetine

製造商/商標名

EDQM

應用

pharmaceutical (small molecule)

形式

neat

儲存溫度

2-8°C

SMILES 字串

CNCC[C@@H](OC1=CC=CC=C1C)C2=CC=CC=C2.[H]Cl

InChI

1S/C17H21NO.ClH/c1-14-8-6-7-11-16(14)19-17(12-13-18-2)15-9-4-3-5-10-15;/h3-11,17-18H,12-13H2,1-2H3;1H/t17-;/m1./s1

InChI 密鑰

LUCXVPAZUDVVBT-UNTBIKODSA-N

基因資訊

human ... SLC6A2(6530)

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一般說明

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

應用

Atomoxetine for impurity A identification EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

生化/生理作用

去甲肾上腺素摄取阻滞剂。

包裝

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他說明

Sales restrictions may apply.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析證明 (COA)

Lot/Batch Number

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Dylan Chou et al.
Experimental neurology, 255, 19-29 (2014-03-04)
Fear conditioning in animals has been used extensively to model clinical anxiety disorders. While individual animals exhibit marked differences in their propensity to undergo fear conditioning, the physiologically relevant mediators have not yet been fully characterized. Here, we demonstrate that
Atomoxetine-induced wake-time teeth clenching and sleep bruxism in a child patient.
Kayhan Bahali et al.
European child & adolescent psychiatry, 23(12), 1233-1235 (2014-08-28)
Angie A Kehagia et al.
Brain : a journal of neurology, 137(Pt 7), 1986-1997 (2014-06-05)
Noradrenergic dysfunction may play a significant role in cognition in Parkinson's disease due to the early degeneration of the locus coeruleus. Converging evidence from patient and animal studies points to the role of noradrenaline in dopaminergically insensitive aspects of the
Atomoxetine-induced mydriasis in a child patient.
Kayhan Bahali et al.
European child & adolescent psychiatry, 23(12), 1231-1232 (2013-11-12)
Claudia E Ramirez et al.
Hypertension (Dallas, Tex. : 1979), 64(6), 1235-1240 (2014-09-04)
The clinical presentation of autonomic failure is orthostatic hypotension. Severely affected patients require pharmacological treatment to prevent presyncopal symptoms or frank syncope. We previously reported in a proof of concept study that pediatric doses of the norepinephrine transporter blockade, atomoxetine

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