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C4206

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卡马西平 10,11-环氧化物

analytical standard

同義詞:

1a,10b-二氢-6H-二苯并(b,f)环氧乙烯并[d]氮呯-6-甲酰胺

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About This Item

經驗公式(希爾表示法):
C15H12N2O2
CAS號碼:
分子量::
252.27
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.24

等級

analytical standard

品質等級

化驗

≥98% (HPLC)

技術

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

應用

forensics and toxicology
pharmaceutical (small molecule)
veterinary

形式

neat

儲存溫度

−20°C

SMILES 字串

NC(=O)N1c2ccccc2C3OC3c4ccccc14

InChI

1S/C15H12N2O2/c16-15(18)17-11-7-3-1-5-9(11)13-14(19-13)10-6-2-4-8-12(10)17/h1-8,13-14H,(H2,16,18)

InChI 密鑰

ZRWWEEVEIOGMMT-UHFFFAOYSA-N

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一般說明

卡马西平10,11-环氧化物是药物卡马西平的代谢产物。

應用

卡马西平10,11-环氧化物可用作测试材料,用于荧光HDAC活性测定法以定量组蛋白脱乙酰酶(HDAC)抑制。
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生化/生理作用

卡马西平的第一代谢产物

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析證明 (COA)

Lot/Batch Number

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Ana Fortuna et al.
Analytical and bioanalytical chemistry, 397(4), 1605-1615 (2010-04-20)
For the first time, a simple, selective and accurate high-performance liquid chromatography method with ultraviolet detection was developed and validated to quantify simultaneously three structurally related antiepileptic drugs; carbamazepine, oxcarbazepine, and the recently launched eslicarbazepine acetate and their main metabolites
Sigrid Mennickent et al.
Journal of separation science, 32(9), 1454-1458 (2009-03-31)
An instrumental planar chromatographic (HPTLC) method for quantification of carbamazepine in human serum was developed using liquid-liquid extraction with dichloromethane, fluorescence activation with perchloric acid 60%/ethanol/water (1:1:1, v/v) and fluorescence detection. Planar chromatographic separation was performed on precoated silica gel
Terumitsu Yoshida et al.
Journal of pharmaceutical and biomedical analysis, 41(4), 1386-1390 (2006-04-07)
This study developed a simple method for the simultaneous determination of zonisamide (ZNS), carbamazepine (CBZ) and its active metabolite, carbamazepine-10,11-epoxide (CBZE) in infant serum using reversed-phase high-performance liquid chromatograph (HPLC). The method involves a single-step protein precipitation procedure that uses
Kyoung-Ah Kim et al.
European journal of clinical pharmacology, 61(4), 275-280 (2005-05-26)
Carbamazepine (CBZ) undergoes biotransformation by CYP3A4 and CYP2C8, and glucuronide conjugation. There has been no clear demonstration to reveal the role of glucuronidation in the disposition of CBZ. We evaluated the effect of probenecid, a UDP-glucuronosyltransferase inhibitor, on the pharmacokinetics
Andreas S Beutler et al.
Life sciences, 76(26), 3107-3115 (2005-04-27)
Carbamazepine (CBZ) is a common antiepileptic drug (AED) that acts through multiple mechanisms including blockade and potentiation of cation channels and modulation of neurotransmitter levels. Whether it affects any component of the gene transcription machinery is unknown. Histone deacetylases (HDAC)

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