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Key Documents

PHR1023

Supelco

茶碱

Pharmaceutical Secondary Standard; Certified Reference Material

同義詞:

1,3-Dimethylxanthine, 2,6-Dihydroxy-1,3-dimethylpurine, 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione

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About This Item

經驗公式(希爾表示法):
C7H8N4O2
CAS號碼:
分子量::
180.16
Beilstein:
13463
EC號碼:
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.24

等級

certified reference material
pharmaceutical secondary standard

品質等級

agency

traceable to BP 327
traceable to Ph. Eur. T080000
traceable to USP 1653004

API 家族

theophylline

CofA

current certificate can be downloaded

技術

HPLC: suitable
gas chromatography (GC): suitable

應用

food and beverages
pharmaceutical (small molecule)

格式

neat

儲存溫度

2-30°C

SMILES 字串

CN1C(=O)N(C)c2[nH]cnc2C1=O

InChI

1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9)

InChI 密鑰

ZFXYFBGIUFBOJW-UHFFFAOYSA-N

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一般說明

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards.
Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards
Theophylline is a methylxanthine drug, most widely prescribed for the management of asthma and chronic obstructive pulmonary disease (COPD).
Theophylline is a xanthine derivative, which is widely found in human diet. It occurs abundantly in chocolate food products.

應用

Theophylline may be used as a pharmaceutical reference standard for the determination of the analyte in drug dosage forms by chromatography and spectrophotometry.
Theophylline may be used as a reference standard in determining the concentration of theophylline present in beverages, food and herbal products using high performance liquid chromatography (HPLC).
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生化/生理作用

Phosphodiesterase inhibitor; diuretic; cardiac stimulant; muscle relaxant; asthma medication.

分析報告

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

其他說明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

腳註

To see an example of a Certificate of Analysis for this material enter LRAA7171 in the slot below. This is an example certificate only and may not be the lot that you receive.

推薦產品

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

象形圖

Skull and crossbonesHealth hazard

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 3 Oral - Repr. 1B

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析證明 (COA)

Lot/Batch Number

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存取文件庫

Simultaneous HPLC determination of caffeine, theobromine, and theophylline in food, drinks, and herbal products
Srdjenovic B, et al.
Journal of Chromatographic Science, 46, 144-149 (2008)
Development and validation of a stability-indicating HPLC method for the simultaneous determination of salbutamol sulphate and theophylline in pharmaceutical dosage forms.
Maithani M and Singh R
Journal of Analytical and Bioanalytical Techniques , 1(116), 11-11 (2011)
Spectrophotometric determination of caffeine and theophylline in pure alkaloids and its application in pharmaceutical formulations.
Singh DK and Sahu A
Analytical Biochemistry, 349(2), 176-180 (2006)
Simultaneous determination of caffeine, theobromine and theophylline in foods and pharmaceutical preparations by using ion chromatography.
Chen QC, et al.
Analytica Chimica Acta, 371(2-3), 287-296 (1998)
Xiao-Feng Sun et al.
Carbohydrate polymers, 92(2), 1357-1366 (2013-02-13)
Hydrogels based on hemicellulose of wheat straw were prepared as a novel carrier for controlled drug delivery. The chemical structure and morphology of the hydrogels were characterised using FT-IR and SEM, respectively. The swelling ratios of the hydrogels were determined

文章

Xanthine is a purine base found in most human body tissues and fluids as well as in other organisms. Methylated xanthines (methylxanthines), which include caffeine, paraxanthine, theobromine, and theophylline, commonly used for their effects as mild stiµlants and as bronchodilators, notably in the treatment of asthma symptoms. This application shows the efficient separation of several common xanthines and may be applied their analysis in any number of desired matrices.

Separation of Hypoxanthine, ≥99.0%; Xanthine, ≥99%; 7-Methylxanthine, ≥98.0% (HPLC); 3-Methylxanthine; 1-Methylxanthine, ≥97.0% (HPLC); Theobromine, ≥98.0%; 1,7-Dimethylxanthine, ~98%, solid; Theophylline, anhydrous, ≥99%, powder; Specimen capsules, microporous, average pore diameter 120 μm

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