推薦產品
等級
certified reference material
形狀
liquid
特點
Snap-N-Spike®/Snap-N-Shoot®
包裝
ampule of 1 mL
製造商／商標名
Cerilliant®
濃度
1.0 mg/mL in methanol
技術
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
應用
clinical testing
格式
single component solution
儲存溫度
−20°C
SMILES 字串
O=C(N)N1C2=CC=CC=C2C3C(O3)C4=CC=CC=C14
InChI
1S/C15H12N2O2/c16-15(18)17-11-7-3-1-5-9(11)13-14(19-13)10-6-2-4-8-12(10)17/h1-8,13-14H,(H2,16,18)
InChI 密鑰
ZRWWEEVEIOGMMT-UHFFFAOYSA-N
一般說明
Carbamazepine-10,11-epoxide is the primary, active metabolite in both urine and serum of carbamazepine, an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder as well as trigeminal neuralgia. Potential toxicity of the epoxide metabolite requires regular therapeutic drug monitoring by LC or LC/MS for patients taking carbamazepine.
應用
- Advanced Analytical Techniques for Carbamazepine Epoxide: A study utilized covalent organic framework-based solid-phase microextraction coupled with electrospray ionization mass spectrometry for sensitive screening and quantitative evaluation of carbamazepine and its metabolite, Carbamazepine-10,11-epoxide, in mice, advancing biochemical research reagents and methodologies (Huang et al., 2022).
- Carbamazepine Metabolite Monitoring: Research developed an HPLC method for the determination of antiepileptic drugs including Carbamazepine-10,11-epoxide in human saliva, facilitating therapeutic drug monitoring and offering a non-invasive technique for patient compliance and drug metabolism studies (Carona et al., 2021).
- Quantitative and Qualitative Analysis of Antiepileptic Drugs: A novel capillary microsampling device, Microsampling Wing (MSW), was evaluated for its effectiveness in handling antiepileptic drugs such as Carbamazepine-10,11-epoxide in rats, enhancing drug discovery processes by providing a minimally invasive sampling method for pharmacokinetic studies (Hotta et al., 2021).
法律資訊
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
訊號詞
Danger
危險分類
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
標靶器官
Eyes
儲存類別代碼
3 - Flammable liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
49.5 °F - closed cup
閃點（°C）
9.7 °C - closed cup
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
客戶也查看了
Ana Fortuna et al.
Analytical and bioanalytical chemistry, 397(4), 1605-1615 (2010-04-20)
For the first time, a simple, selective and accurate high-performance liquid chromatography method with ultraviolet detection was developed and validated to quantify simultaneously three structurally related antiepileptic drugs; carbamazepine, oxcarbazepine, and the recently launched eslicarbazepine acetate and their main metabolites
Sigrid Mennickent et al.
Journal of separation science, 32(9), 1454-1458 (2009-03-31)
An instrumental planar chromatographic (HPTLC) method for quantification of carbamazepine in human serum was developed using liquid-liquid extraction with dichloromethane, fluorescence activation with perchloric acid 60%/ethanol/water (1:1:1, v/v) and fluorescence detection. Planar chromatographic separation was performed on precoated silica gel
Terumitsu Yoshida et al.
Journal of pharmaceutical and biomedical analysis, 41(4), 1386-1390 (2006-04-07)
This study developed a simple method for the simultaneous determination of zonisamide (ZNS), carbamazepine (CBZ) and its active metabolite, carbamazepine-10,11-epoxide (CBZE) in infant serum using reversed-phase high-performance liquid chromatograph (HPLC). The method involves a single-step protein precipitation procedure that uses
[Carbamazepine-associated pseudolymphoma].
J F Muñoz-Cerón et al.
Revista de neurologia, 43(11), 700-702 (2006-11-30)
Bahram Hemmateenejad et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 68(3), 718-724 (2007-02-20)
Carbamazepine (CBZ) undergoes enzyme biotransformation through epoxidation with the formation of its metabolite, carbamazepine-10,11-epoxide (CBZE). A simple chemometrics-assisted spectrophotometric method has been proposed for simultaneous determination of CBZ and CBZE in plasma. A liquid extraction procedure was operated to separate
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