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Merck
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重要文件

574661

Sigma-Aldrich

Survivin Antagonist, S12

The Survivin Antagonist, S12 controls the biological activity of Survivin.

同義詞:

Survivin Antagonist, S12, Survivin Inhibitor II, 3-(2-(benzo[d][1,3]dioxol-5-yl)-2-oxoethyl)-5-bromo-3-hydroxyindolin-2-one

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About This Item

經驗公式(希爾表示法):
C17H12BrNO5
CAS號碼:
分子量::
390.18
MDL號碼:
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

化驗

≥98% (HPLC)

形狀

solid

製造商/商標名

Calbiochem®

儲存條件

OK to freeze
protect from light

顏色

white

溶解度

DMSO: 50 mg/mL, nearly colorless

運輸包裝

ambient

儲存溫度

−20°C

SMILES 字串

O=C(CC1(C(C=C(Br)C=C2)=C2NC1=O)O)C3=CC(OCO4)=C4C=C3

InChI

1S/C17H12BrNO5/c18-10-2-3-12-11(6-10)17(22,16(21)19-12)7-13(20)9-1-4-14-15(5-9)24-8-23-14/h1-6,22H,7-8H2,(H,19,21)

InChI 密鑰

WFYHAKOLBICHEZ-UHFFFAOYSA-N

一般說明

A cell-permeable hydroxyindolinone compound that acts as a selective antagonist of survivin. Induces mitotic arrest and blocks cell cycle at G2/M phase (~40 µM in HeLA cells) leading to apoptotic cell death. Shown to bind to a specific cavity adjacent to the interface involved in the dimerization of survivin. Binding is specific only to native survivin and does not affect any mutant forms. Inhibits HCT116 cell proliferation independently of their p53 status and reduces tumor volume in xenograft models in a dose-dependent manner (5 to 15 mg/kg).

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Berezov, A., et al. 2011. Oncogene31, 1938.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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