440205-M

LY 83583

A cell-permeable, competitive inhibitor of soluble guanylate cyclase (IC₅₀ = 2 µM).

• 同義詞: LY 83583, 6-Anilino-5,8-quinolinequinone
• 經驗公式（希爾表示法）: C₁₅H₁₀N₂O₂
• CAS號碼: 91300-60-6
• 分子量：: 250.25
• MDL號碼: MFCD00210756
• 分類程式碼代碼: 12352200

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze
• 顏色: red-purple
• 溶解度: ethanol: 3 mg/mL; acetone: soluble
• 儲存溫度: 2-8°C
• SMILES 字串: N(c3ccccc3)C1=CC(=O)c2ncccc2C1=O
• InChI: 1S/C15H10N2O2/c18-13-9-12(17-10-5-2-1-3-6-10)15(19)11-7-4-8-16-14(11)13/h1-9,17H
• InChI 密鑰: GXIJYWUWLNHKNW-UHFFFAOYSA-N

描述

一般說明

A cell-permeable, competitive inhibitor of soluble guanylate cyclase (IC₅₀ = 2 µM). Lowers the production of cGMP levels in a wide range of tissues by blocking intracellular Ca²⁺ release, with negligible effect on cAMP levels. Inhibits nitric oxide-induced smooth muscle relaxation. Shown to inhibit interleukin-1-induced cGMP accumulation in cultured rat aortic vascular smooth muscle cells. Also inhibits neutrophil chemotaxis induced by NO donors.

生化／生理作用

Primary Target
soluble guanylate cyclase

Target IC₅₀: 2 µM against soluble guanylate cyclase

警告

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

重構

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 month at 4°C or up to 6 months at -20°C.

其他說明

Adachi, R., et al. 2000. Int. J. Immunopharmacol. 22, 855.
Kawada, T., et al. 1994. Gen. Pharmacol. 25, 1361.
Beasley, D., et al. 1991. J. Clin. Invest. 87, 602.
Pandol, S.J., et al. 1990. J. Biol. Chem.265, 12846.
Light, D.B., et al. 1989. Science 243, 383.
Mulsch, A. 1988. J. Pharmacol. Exp. Ther.247, 283.
Fleisch, J.H., et al. 1984. J. Pharmacol. Exp. Ther. 229, 681.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable