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Key Documents

C2920

Sigma-Aldrich

羰基氰化物 4-(三氟甲氧基)苯腙

≥98% (TLC), powder, Mitophagy inducer

同義詞:

FCCP, 羰基氰对三氟甲氧基苯腙

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About This Item

線性公式:
CF3OC6H4NHN=C(CN)2
CAS號碼:
分子量::
254.17
Beilstein:
664446
EC號碼:
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

product name

羰基氰化物 4-(三氟甲氧基)苯腙, ≥98% (TLC), powder

品質等級

化驗

≥98% (TLC)

形狀

powder

顏色

yellow

mp

174-175 °C (dec.) (lit.)

溶解度

95% ethanol: soluble

儲存溫度

2-8°C

SMILES 字串

FC(F)(F)Oc1ccc(N\N=C(/C#N)C#N)cc1

InChI

1S/C10H5F3N4O/c11-10(12,13)18-9-3-1-7(2-4-9)16-17-8(5-14)6-15/h1-4,16H

InChI 密鑰

BMZRVOVNUMQTIN-UHFFFAOYSA-N

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一般說明

FCCP是一种质子载体(H+ 离子载体),也是线粒体氧化磷酸化的解偶联剂。它能够促使质膜和线粒体膜去极化。FCCP可影响细胞钙离子参与的各种活动。它还能抑制K+ 背景电流和诱导小量内向电流,降低0.1单位的pH,以及诱导胞内[Na+]升高。FCCP能刺激Mg2+-ATP酶活性,抑制β-淀粉样蛋白生成,以及模拟选择性谷氨酸激动剂N-甲基-D-天冬氨酸(NMDA)对线粒体超氧化物产生的影响。

應用

碳酰腈4-三氟甲氧基苯腙(FCCP)可作为细胞培养的解偶联剂:用于研究其对产热脂肪细胞的影响,用于研究其对小鼠线粒体β-氧化的作用,用于研究其对小鼠骨髓来源树突状细胞的代谢影响。

象形圖

CorrosionExclamation mark

訊號詞

Danger

危險分類

Acute Tox. 4 Oral - Aquatic Chronic 4 - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


分析證明 (COA)

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