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T-075

Supelco

3,3′,5′-三碘代-甲腺原氨酸（rT3）标准液 溶液

100 μg/mL in methanol with 0.1N NH3, ampule of 1 mL, certified reference material, Cerilliant®

同義詞:

3,3',5'-三碘- L -甲状腺氨酸, rT(3), 逆转 T 3

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About This Item

經驗公式（希爾表示法）:
C15H12I3NO4
CAS號碼:
5817-39-0
分子量：:
650.97
MDL號碼:
MFCD00036864
分類程式碼代碼:
41116107
PubChem物質ID:
329826619
NACRES:
NA.24

等級

certified reference material

品質等級

300

形狀

liquid

特點

Snap-N-Spike®/Snap-N-Shoot®

包裝

ampule of 1 mL

製造商／商標名

Cerilliant®

濃度

100 μg/mL in methanol with 0.1N NH3

技術

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

應用

clinical testing
clinical testing

形式

single component solution

儲存溫度

−20°C

SMILES 字串

N[C@@H](Cc1ccc(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O

InChI

1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)/t12-/m0/s1

InChI 密鑰

HZCBWYNLGPIQRK-LBPRGKRZSA-N

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相關類別

一般說明

反向T3，也称为rT3或3,3′,5′-三碘-L-甲状腺原氨酸，是甲状腺激素T3的一种生物失活形式，是在体内，特别是在压力期间产生的。在某些情况，如纤维肌痛、肝病和慢性疲劳综合症（CFS）时，更多的rT3会被产生，从而最大限度地减少所需要的甲状腺素（T4）向T3转化。通过LC-MS/MS测量反向T3血清浓度，以监测这些疾病和其他疾病对甲状腺激素水平的影响。

法律資訊

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

訊號詞

Danger

危險分類

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 3 - Flam. Liq. 2 - STOT SE 1

標靶器官

Eyes,Central nervous system

儲存類別代碼

3 - Flammable liquids

水污染物質分類（WGK）

WGK 2

閃點（°F）

49.5 °F - closed cup

閃點（°C）

9.7 °C - closed cup

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分析證明 (COA)

Lot/Batch Number

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S Ruhla et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 43(2), 130-134 (2010-11-26)
Thyroid dysfunction has been shown to be associated with insulin resistance (IR). This may involve peripheral thyroid hormone metabolism, which is assumed to be reflected by the ratio triiodothyronine/reverse triiodothyronine (T3/rT3-ratio). To explore a potential association between the T3/rT3-ratio and
Ashley Hinther et al.
Environmental science & technology, 44(21), 8314-8321 (2010-10-12)
Nanometals are manufactured to particle sizes with diameters in the nanometer range and are included in a variety of consumer and health products. There is a lack of information regarding potential effects of these materials on aquatic organisms. Amphibians are
Annemieke J Lem et al.
The Journal of clinical endocrinology and metabolism, 97(9), 3170-3178 (2012-06-28)
Age-appropriate reference ranges for thyroid hormones are required for detecting pediatric thyroid dysfunction. Data on thyroid hormones and peripheral thyroid metabolism in short children born small for gestational age (SGA) before and during GH treatment are lacking. Our objectives were
R Kassem et al.
Clinical and experimental dermatology, 37(8), 850-856 (2012-10-23)
Different elements of the hypothalamic-pituitary-thyroid axis have been found to be implicated in the normal physiology of the human skin. Their effects on wound healing and hair growth in rats have been described previously. There is close homology between the
Pranati Sar et al.
PloS one, 6(6), e20861-e20861 (2011-06-21)
Thyroid hormones regulate cell proliferation, differentiation as well as apoptosis. However molecular mechanism underlying apoptosis as a result of thyroid hormone signaling is poorly understood. The antiapoptotic role of Senescence Marker Protein-30 (SMP30) has been characterized in response to varieties
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Online SPE/LC-MS Method for the Rapid Analysis of Thyroid Hormones in Plasma

Determination of the thyroid hormones T4, T3 and rT3 from plasma using an Ascentis Express RP-Amide cartridge to trap the analytes, and a Phenyl-Hexyl column to resolve them.

Online Solid Phase Extraction and LC-MS Analysis of Thyroid Hormones in Human Serum

Thyroid hormones play critical roles in the regulation of biological processes, such as growth, metabolism, protein synthesis, and brain development. For a clinical laboratory, fast and reliable measurements of total hormone levels are important for the diagnosis and monitoring of thyroid diseases.

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