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765139

Sigma-Aldrich

聚(乙二醇)甲醚-嵌段-聚（丙交酯-共-乙交酯）

PEG average Mn 5,000, PLGA Mn 7,000

同義詞:

PEG-PLGA, mPEG-b-PLGA

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About This Item

線性公式:
H[(C3H4O2)x(C2H2O2)y]mO[C2H4O]nCH3
分類程式碼代碼:
12162002
NACRES:
NA.23

形狀

solid

品質等級

100

饋電比

lactide:glycolide 50:50

分子量

PEG average Mn 5,000
PLGA Mn 7,000
average Mn 12,000 (total)

降解時間

1-4 weeks

轉變溫度

Tg 24 °C
Tm 38-43 °C

蛋白質二硫鍵異構酶

<2.0

儲存溫度

2-8°C

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相關類別

一般說明

两亲性嵌段共聚物（AmBC）由两种化学上不同的均聚物嵌段组成。嵌段之一是亲水的，另一个是疏水的。这些大分子溶于水介质时具有自组装的特性。PEG-PLGA是最常用于药物递送应用的可生物降解的两亲嵌段共聚物之一。PEG是亲水部分，PLGA是疏水部分。

應用

可用于合成靶向纳米粒子，从而用于差异递送和控释药物。
形成“隐形”聚乙二醇化微粒

特點和優勢

  • 良好的生物相容性、低免疫原性和良好的降解性。
  • 通过改变嵌段共聚物链段的尺寸可以轻松调节其性能，以适合特定应用。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

No data available

閃點（°C）

No data available

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分析證明 (COA)

Lot/Batch Number
MKCQ8258
MKCG9123
MKCG9125
MKCG9127
MKCG1452

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Thermosensitive self-assembling block copolymers as drug delivery systems.
Bonacucina, G., Cespi, M., Mencarelli, G., Giorgioni, G., &amp; Palmieri, G. F.
Polymer, 3(2), 779-811 (2011)
Frank Gu et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(7), 2586-2591 (2008-02-15)
There has been progressively heightened interest in the development of targeted nanoparticles (NPs) for differential delivery and controlled release of drugs. Despite nearly three decades of research, approaches to reproducibly formulate targeted NPs with the optimal biophysicochemical properties have remained
PLGA-PEG Encapsulated sitamaquine nanoparticles drug delivery system against Leishmania donovani
Kumara, R., Sahoo, G. C., Pandeya, K., Dasa, V. N. R., Yousuf, M., Ansaria, S. R., &amp; Dasa, P.
Journal of Scientific and Innovative Research, 3(1), 85-90 (2014)

文章

Solubility enhancement of hydrophobic drugs via drug-loaded micelles using biodegradable PEG- polyester diblock copolymers

One of the common difficulties with intravenous drug delivery is low solubility of the drug. The requirement for large quantities of saline to dissolve such materials limits their clinical use, and one solution for this problem that has recently generated interest is the formation of drug-loaded micelles.

Electrospun Nanofibers for Drug Delivery Systems

Local delivery of bioactive molecules using an implantable device can decrease the amount of drug dose required as well as non-target site toxicities compared to oral or systemic drug administration.

Fabrication of Drug-loaded Microparticles Using Hydrogel Technology and Recent Innovation in Automation

Microparticle drug delivery systems have been extensively researched and applied to a wide variety of pharmaceutical and medical applications due to a number of advantages including injectability, local applicability to target tissues and sites, and controlled drug delivery over a given time period.

Polymersomes for Drug Delivery

The development of drugs that target specific locations within the human body remains one of the greatest challenges in biomedicine today.

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