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764825

Sigma-Aldrich

聚(乙二醇)甲醚-嵌段-聚（丙交酯-共-乙交酯）

PEG Mn 2,000, PLGA Mn 4,500

同義詞:

PEG-PLGA, mPEG-b-PLGA

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About This Item

線性公式:
H[(C3H4O2)x(C2H2O2)y]mO[C2H4O]nCH3
分類程式碼代碼:
12162002
NACRES:
NA.23

形狀

pellets

品質等級

100

饋電比

lactide:glycolide 65:35

分子量

PEG Mn 2,000
PLGA Mn 4,500
average Mn 6,500 (total)

降解時間

1-4 weeks

轉變溫度

Tm 241-246 °C

蛋白質二硫鍵異構酶

≤2.0

儲存溫度

2-8°C

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相關類別

一般說明

两亲性嵌段共聚物 (AmBC) 由两种化学结构不同的均聚物嵌段组成。其中一个是亲水性的，另一个是疏水性的。这些大分子在水性介质中溶解时具有自组装的属性。PEG-PLGA 是一种最常用的可生物降解的两亲性嵌段共聚物，用于药物输送。PEG 是亲水性部分，PLGA 是疏水性部分。

應用

形成“隐形”聚乙二醇化微粒
用于合成用于药物差异递送和控释的靶向纳米粒子。

特點和優勢

  • 生物相容性好，免疫原性低，可降解性好。
  • 通过改变嵌段共聚物链段大小以适应特定的应用，可以很容易地调节性质。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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分析證明 (COA)

Lot/Batch Number
MKCQ6851
MKCM0439
MKCK2243
MKCJ4906
MKCF5968

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Thermosensitive self-assembling block copolymers as drug delivery systems.
Bonacucina, G., Cespi, M., Mencarelli, G., Giorgioni, G., & Palmieri, G. F.
Polymer, 3(2), 779-811 (2011)
Frank Gu et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(7), 2586-2591 (2008-02-15)
There has been progressively heightened interest in the development of targeted nanoparticles (NPs) for differential delivery and controlled release of drugs. Despite nearly three decades of research, approaches to reproducibly formulate targeted NPs with the optimal biophysicochemical properties have remained
PLGA-PEG Encapsulated sitamaquine nanoparticles drug delivery system against Leishmania donovani
Kumara, R., Sahoo, G. C., Pandeya, K., Dasa, V. N. R., Yousuf, M., Ansaria, S. R., & Dasa, P.
Journal of Scientific and Innovative Research, 3(1), 85-90 (2014)

文章

Solubility enhancement of hydrophobic drugs via drug-loaded micelles using biodegradable PEG- polyester diblock copolymers

One of the common difficulties with intravenous drug delivery is low solubility of the drug. The requirement for large quantities of saline to dissolve such materials limits their clinical use, and one solution for this problem that has recently generated interest is the formation of drug-loaded micelles.

Electrospun Nanofibers for Drug Delivery Systems

Local delivery of bioactive molecules using an implantable device can decrease the amount of drug dose required as well as non-target site toxicities compared to oral or systemic drug administration.

Fabrication of Drug-loaded Microparticles Using Hydrogel Technology and Recent Innovation in Automation

Microparticle drug delivery systems have been extensively researched and applied to a wide variety of pharmaceutical and medical applications due to a number of advantages including injectability, local applicability to target tissues and sites, and controlled drug delivery over a given time period.

Biodegradable Polyester Based Nanoparticle Formation by Miniemulsion Technique

Aliphatic polyesters such as polylactide, poly(lactide-co-glycolide) and polycaprolactone, as well as their copolymers, represent a diverse family of synthetic biodegradable polymers that have been widely explored for medical uses and are commercially available.

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