T5580

粘噻唑

from Myxococcus fulvus Mx f85, ≥98% (HPLC), lyophilized solid, antibiotic

• 别名: Myxothiazol A
• 经验公式（希尔记法）: C₂₅H₃₃N₃O₃S₂
• CAS号: 76706-55-3
• 分子量: 487.68
• MDL號碼: MFCD00043397
• 分類程式碼代碼: 51111800
• PubChem物質ID: 329826828
• NACRES: NA.77

属性

• product name: 粘噻唑, from Myxococcus fulvus Mx f85, ≥98% (HPLC)
• 生物源: Myxococcus fulvus Mx f85
• 品質等級: 200
• 化驗: ≥98% (HPLC)
• 儲存條件: protect from light; under inert gas
• 溶解度: chloroform: soluble 9.80-10.20 mg/mL, clear, colorless to yellow; DMSO: soluble; acetone: soluble; dichloromethane: soluble; ethanol: soluble; ethyl acetate: soluble; methanol: soluble
• 抗生素活性譜: fungi
• 作用方式: enzyme | inhibits
• 儲存溫度: −20°C
• SMILES 字串: CO[C@@H](\C=C\c1csc(n1)-c2csc(n2)[C@@H](C)\C=C\C=C\C(C)C)[C@@H](C)\C(OC)=C\C(N)=O
• InChI: 1S/C25H33N3O3S2/c1-16(2)9-7-8-10-17(3)24-28-20(15-33-24)25-27-19(14-32-25)11-12-21(30-5)18(4)22(31-6)13-23(26)29/h7-18,21H,1-6H3,(H2,26,29)/b9-7+,10-8+,12-11+,22-13-/t17-,18+,21-/m0/s1
• InChI 密鑰: XKTFQMCPGMTBMD-ZDBABOMLSA-N

说明

應用

Myxothiazol has been used as a complex IIIQo inhibitor in C. elegans cultures⁵. It has also been used to analyze mitochondrial oxygen transport in rat cells⁶.

Myxothiazol has been used in as a mitochondrial electron transport chain (mETC) inhibitor in P19 murine embryonal carcinoma pluripotent cell line and to treat HeLa cells for integrated stress response activation.

生化／生理作用

Myxothiazol, an antibiotic with activity against fungi and insects, is a strong inhibitor of mitochondrial cytochrome b/c₁-segment of respiratory chain. Myxothiazol binds to the quinol oxidation (Qo) site of the bc1 complex, blocking electron transfer to the Rieske iron-sulfur protein in the mitochondrial respiratory chain. Oxygen consumption blockage leads to a cytostatic effect that could be reversed. Myxothiazol, as other Epothilones, which are known for their anti tumor activity, contains a thiazole ring that is formed by the incorporation of cysteine into the polyketide backbone.

準備報告

Myxothiazol dissolves in chloroform at 9.80 - 10.20 mg/ml to yield a clear, colorless to yellow solution. It is also soluble in DMSO, acetone, dichloromethane, ethanol, ethyl acetate and methanol.

安全信息

• 象形圖: GHS06
• 訊號詞: Danger
• 危險聲明: H300
• 防範說明: P264 - P270 - P301 + P310 - P405 - P501
• 危險分類: Acute Tox. 2 Oral
• 儲存類別代碼: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable