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化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 2 mg/mL, clear
儲存溫度
2-8°C
SMILES 字串
ClC1=CC=C(N2C(C)=CC(C(CN3CCCCC3)=O)=C2C)C=C1
生化／生理作用
IU1-47 is a potent and selective inhibitor of the deubiquitinating enzyme UPS14. IU1-47 enhances protein degradation including human wild-type and pathological Tau forms in neurons.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Monica Boselli et al.
The Journal of biological chemistry, 292(47), 19209-19225 (2017-10-04)
The ubiquitin-proteasome system (UPS) is responsible for most selective protein degradation in eukaryotes and regulates numerous cellular processes, including cell cycle control and protein quality control. A component of this system, the deubiquitinating enzyme USP14, associates with the proteasome where
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