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化驗
≥98%
品質等級
溶解度
DMSO or DMF: 25 mg/mL
儲存溫度
−20°C
SMILES 字串
CC(C)C[C@@H](C(N[C@H](C(N[C@H](C=O)CC(C)C)=O)CC(C)C)=O)NC(OCC1=CC=CC=C1)=O
應用
(R)-MG132已被用于泛素化测定并用作蛋白酶体抑制剂。
生化／生理作用
MG132(carbobenzoxy-Leu-Leu-leucinal)是一种三肽醛。它具有抗肿瘤活性，可增强化疗和放疗的细胞抑制/细胞毒性作用。(R)-MG132是一种有效的膜渗透性蛋白酶体抑制剂。它可以抑制J558L多发性骨髓瘤细胞和EMT6乳腺癌细胞裂解物中的蛋白酶体活性。与(S)-MG132相比，(R)-MG132立体异构体是更有效的胰凝乳蛋白酶样（ChTL）、胰蛋白酶样（TL）和肽酰谷氨酰肽水解蛋白酶体（PGPH）活性抑制剂。
外觀
结晶固体或过冷液体
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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