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About This Item
经验公式（希尔记法）:
C18H14N4O2
CAS号:
分子量:
318.33
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
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品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 20 mg/mL, clear
儲存溫度
2-8°C
SMILES 字串
OC1=CC(OC2=NC=NC3=C2C=C(C4=CC=CC(N)=C4)N3)=CC=C1
InChI
1S/C18H14N4O2/c19-12-4-1-3-11(7-12)16-9-15-17(22-16)20-10-21-18(15)24-14-6-2-5-13(23)8-14/h1-10,23H,19H2,(H,20,21,22)
InChI 密鑰
VPVLEBIVXZSOMQ-UHFFFAOYSA-N
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應用
TWS119已被用作糖原合酶激酶3β（GSK-3β）GSK3β抑制剂。
生化／生理作用
TWS119可通过激活哺乳动物雷帕霉素靶标（mTOR）途径促进γδT细胞的存活和增殖。它还可以促进T细胞因子1（TCF1）的表达并调节细胞因子的生成。
TWS119是一种可以诱导胚胎干细胞（ESC）中神经生成的有效糖原合酶激酶3β（GSK-3β）抑制剂。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
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