推荐产品
product name
雷帕霉素, Ready Made Solution, 2.5 mg/mL in DMSO (2.74 mM), from Streptomyces hygroscopicus
品質等級
化驗
≥95% (HPLC)
形狀
solution
製造商/商標名
Calbiochem®
儲存條件
desiccated (hygroscopic)
protect from light
運輸包裝
wet ice
儲存溫度
−20°C
一般說明
选择性抑制 p70 S6 激酶的磷酸化和激活(IC50 = 50 pM)。防止 IGF-II 的翻译激活。还防止静止的 T 细胞进入细胞周期,但不直接阻止细胞周期进程。研究表明,可抑制随后的信号传导事件,例如 p110Rb 磷酸化、p34cdc2 激酶激活和细胞周期蛋白 A 合成。表现出与 FK-50 6结合蛋白的强结合力。还据报道在鼠 B 细胞系中诱导凋亡,抑制淋巴因子诱导的细胞增殖(在 G1 期),并不可逆地阻滞酿酒酵母细胞(在 G1 期)。
生化/生理作用
主靶
雷帕霉素(mTOR)的哺乳动物靶标
雷帕霉素(mTOR)的哺乳动物靶标
产物不与ATP竞争。
可逆:否
细胞渗透性:否
靶标IC50:50 pM 抑制雷帕霉素(mTOR)的哺乳动物靶标,并阻断随后的 p70 S6 激酶的激活
包裝
用惰性气体包装
警告
毒性:刺激性(B)
外觀
5 mM(500 µg/109 µl)雷帕霉素溶液(货号553210),溶剂为DMSO
重構
初次使用后,等分并冷冻(-20°C)。
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
10 - Combustible liquids
水污染物質分類(WGK)
WGK 1
閃點(°F)
188.6 °F - closed cup - (Dimethylsulfoxide)
閃點(°C)
87 °C - closed cup - (Dimethylsulfoxide)
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