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R8781

Sigma-Aldrich

雷帕霉素

from Streptomyces hygroscopicus, ≥95% (HPLC), solution, mTOR inhibitor

别名:

雷帕霉素 溶液

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About This Item

经验公式（希尔记法）:
C51H79NO13
分子量:
914.17
EC號碼:
200-664-3
分類程式碼代碼:
12352200
NACRES:
NA.77

产品名称

雷帕霉素, Ready Made Solution, 2.5 mg/mL in DMSO (2.74 mM), from Streptomyces hygroscopicus

生物源

Streptomyces hygroscopicus

品質等級

300

蒸汽壓力

0.56 hPa ( 20 °C)

化驗

≥95% (HPLC)

形狀

solution

自燃溫度

301 °C

濃度

2.5 mg/mL in DMSO (2.74 mM)

顏色

colorless to yellow

抗生素活性譜

fungi
yeast

作用方式

enzyme | inhibits

儲存溫度

−20°C

相关类别

一般說明

雷帕霉素是一种具有有效的免疫抑制剂和抗癌活性的大环三烯抗生素。它可与FKBP12形成能与雷帕霉素分子靶标（mTOR）结合并对其进行抑制的复合物。mTOR是磷酸肌醇激酶相关激酶（PIKK）家族的成员，该家族可通过磷酸肌醇3-激酶/Akt信号通路增强细胞增殖。通过雷帕霉素阻断可导致G1细胞周期阻滞的下游元素而对该通路进行抑制。mTOR作用的效应子包括4EBP1和S6K1。
Rapamycin, an mTOR inhibitor, is derived from Streptomyces hygroscopicus. It can inhibit viral replication. This natural anti-fungal antibiotic is a proven anti-aging agent. Rapamycin significantly inhibits mTORC1 regardless of age.

應用

Rapamycin has been used:
  • as a supplement in mTeSR1 medium to culture induced pluripotent stem cell (iPSC) colonies for induction of autophagy signaling
  • to treat the Drosophila S2 cells at 65-70% confluence,
  • to measure protein synthesis
  • to stimulate autophagy in ovarian cancer cells

包裝

200uL

其他說明

2024年CiteAb奖——成功的帕金森研究供应商(2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research)
保存于密闭容器内，置于干燥通风处。惰性气体中保存。是吸湿性的。
雷帕霉素已经过专家审查并被化学探针门户网站所推荐。如需更多信息，请访问化学探针门户网站上的雷帕霉素探针摘要。

儲存類別代碼

10 - Combustible liquids

水污染物質分類（WGK）

WGK 1

閃點（°F）

188.6 °F - closed cup

閃點（°C）

87 °C - closed cup

個人防護裝備

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

从最新的版本中选择一种：

分析证书(COA)

Lot/Batch Number
11181131
118M4155V
11180805
087M4106V
11170316

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