推荐产品
product name
Pitstop 2, ≥98% (HPLC)
品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to light brown
溶解度
DMSO: 20 mg/mL, clear
儲存溫度
−20°C
應用
Pitstop 2 已被用作网格蛋白介导内吞作用的抑制剂。
生化／生理作用
Pitstop 2 是网格蛋白介导内吞作用的选择性抑制剂。
Pitstop 2 是网格蛋白介导内吞作用的选择性抑制剂，通过阻断配体进入网格蛋白末端结构域发挥作用。Pitstop 2 能选择性抑制网格蛋白介导的 HIV 进入，并阻止网格蛋白包覆的pit (CCP) 动力学。
Pitstop 2 还具有破坏核孔复合体 (NPC) 通透性屏障和降低输入蛋白 β结合，同时改变 NPC 超微结构。Pitstop 2 还参与抑制血小板活化、血小板聚集和分泌。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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Maria S Ioannou et al.
Cell, 177(6), 1522-1535 (2019-05-28)
Metabolic coordination between neurons and astrocytes is critical for the health of the brain. However, neuron-astrocyte coupling of lipid metabolism, particularly in response to neural activity, remains largely uncharacterized. Here, we demonstrate that toxic fatty acids (FAs) produced in hyperactive
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Neuron, 100(1), 91-105 (2018-08-28)
AMPA receptors are essential for fast excitatory transmission in the CNS. Autoantibodies to AMPA receptors have been identified in humans with autoimmune encephalitis and severe defects of hippocampal function. Here, combining electrophysiology and high-resolution imaging with neuronal culture preparations and
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